Real-life Effectiveness of Vortioxetine in Depression

Inclusion Criteria: * The patient is ≥18 years * The patient is an outpatient, treated in a GP or psychiatric outpatient practice * The patient has a diagnosis of major depressive episode according to local diagnostic criteria * The patient has been prescribed vortioxetine according to the local Summary of Product Characteristics (SmPC) Exclusion Criteria: * The patient is unable to read and understand the information sheet and informed consent form or the Patient Reported Outcomes (PRO) * The patient is concurrently participating in a clinical trial * The patient has a diagnosis of schizophrenia or other psychotic disorder according to local diagnostic criteria * The patient has a diagnosis of bipolar disorder according to local diagnostic criteria * The patient has a substance use disorders other than tobacco use disorder * The patient has dementia or other neurodegenerative disease significantly impacting cognitive functioning * The patient has a mood disorder due to a general medical condition or substances * The patient is pregnant, ≤6 months post-partum or breastfeeding * The patient is at significant risk of suicide in the investigator's opinion or the patient has attempted suicide within the last six months * The patient is a member of the study personnel or of their immediate families, or is a subordinate (or immediate family member of a subordinate) to any of the study personnel