The purpose of this study was to evaluate the safety, tolerability, and pharmacokinetics (PK) of ACH-0144471 (danicopan) in participants with hepatic impairment (HI) as compared to healthy matched participants.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
16
Oral tablet.
Clinical Trial Site
Miami, Florida, United States
Clinical Trial Site
Orlando, Florida, United States
Area Under The Plasma Concentration Versus Time Curve From Time 0 Extrapolated To Infinity (AUC0-inf) Of Danicopan
Time frame: Up to 72 hours postdose
Area Under The Plasma Concentration Versus Time Curve From Time 0 To The Last Measurable Concentration (AUC0-t) Of Danicopan
Time frame: Up to 72 hours postdose
Maximum Observed Plasma Concentration (Cmax) Of Danicopan
Time frame: Up to 72 hours postdose
Time To Maximum Observed Plasma Concentration (Tmax) Of Danicopan
Time frame: Up to 72 hours postdose
Participants Experiencing Treatment-emergent Adverse Events
Time frame: Day 1 (postdose) through follow-up visit (10 [+/- 2] days after last study drug administration)
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