This study evaluates the effects of a whole-body electromyostimulation (WB-EMS) training combined with individualized nutritional support on skeletal muscle mass, body composition, muscle strength/function, quality of life, fatigue, pain and gastrointestinal symptoms in patients with hematological malignancies 4-6 weeks before and 4-6 weeks after undergoing stem cell Transplantation. Within this context, this study also investigates the effect of the nutrition and exercise intervention on the period of hospitalization, period of White blood cell recovery and frequency and severity of complications (mucositis, Graft-versus-Host-Disease, infections) after stem cell Transplantation as consequences of the therapeutic immune Suppression.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
40
WB-EMS training is performed 2x/week for a total of 12 weeks; Stimulation protocol: Frequency of 85 Hz, pulse duration of 0.35 ms, stimulation period of 6 sec, resting period of 4 sec; supervised by certified training instructors/physiotherapists participants perform simple exercises during the stimulation period following a video tutorial
Department of Medicine 1, Hector Center for Nutrition, Exercise and Sports, Friedrich-Alexander-University Erlangen-Nuremberg
Erlangen, Germany
RECRUITINGSkeletal muscle mass
Skeletal muscle mass assessed by bioelectrical impedance analysis (in kg)
Time frame: 12 weeks
Physical function - Isometric muscle strength
Hand grip strength assessed by hand dynamometer (in kg)
Time frame: 12 weeks
Cardiorespiratory Fitness
VO2max assessed by spirometry
Time frame: 12 weeks
Patient-reported Quality of Life (QoL)
EORTC QLQ - C30 questionnaire
Time frame: 12 weeks
Patient-reported Fatigue
FACIT-Fatigue scale
Time frame: 12 weeks
Depression/Anxiety
Hospital Anxiety and Depression Scale
Time frame: 12 weeks
Inflammatory blood markers
Blood collection and analysis (Albumin, CRP, Cytokines)
Time frame: 12 weeks
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