Adenosine Contrast CorrELations in Evaluating RevAscularizaTION

Inclusion Criteria: 1. Have the capacity to understand and sign an informed consent or have a legally authorized representative (LAR) that can understand and sign an informed consent prior to initial arteriotomy access 2. Age \> 18 years of age at the time of signing the informed consent 3. Clinically stable and undergoing non-emergent cardiac catheterization for appropriate indications 4. Willing to be contacted by telephone at 30 days (if no standard of care visit) and at 1 year with chart review for events. 5. Target vessel with an intermediate lesion of 40-70% stenosis by angiographic assessment (a visual estimation by the operator). Serial lesions, diffuse disease, or ostial lesions ("all-comer" lesions) are acceptable if the operator would normally perform FFR and proceed with PCI (or other revascularization) if positive. Exclusion Criteria: 1. Any condition associated with a life expectancy of less than 1 year 2. Participation in another clinical study using an investigational agent or device within the past 3 months 3. Ejection fraction ≤ 35% 4. Creatinine ≥ 2 5. Severe valvular heart disease 6. Decompensated acute diastolic or systolic heart failure 7. Bronchospastic chronic obstructive pulmonary disease or other intolerance to adenosine 8. ST-segment elevation myocardial infarction culprit lesion or lesions with any thrombus burden after diagnostic angiography 9. Lesions with severe calcification after diagnostic angiography 10. Lesions in a target vessel supplied by a patent graft