This protocol serves as a mechanism to collect, store, and distribute bodily fluid and tissue samples obtained from Hematopoietic Cell Transplant (HCT) or novel immunotherapy patients and their donors at the Masonic Cancer Center in order to conduct correlative studies of the immune system, microbiota, and their interactions. Fluid (including but not limited to, blood, urine, saliva, cerebrospinal fluid, bronchoalveolar lavage fluid) sample log-in, processing, relabeling, and storage is performed by the Masonic Cancer Center (MCC) Translational Therapy Lab (TTL).
Study Type
OBSERVATIONAL
Enrollment
210
60 ml heparinized blood 10 ml serum
pea-sized amount
10 ml
10 ml
rectosigmoid site preferred
2-4 mm punch
Involved skin, mouth, and/or ocular swab for microbiota studies
Up to 10 ml of apheresis product
A second washing from the infusion bag after product and initial bag wash has infused, or up to 10 ml of final cellular product
University of Minnesota Masonic Cancer Center
Minneapolis, Minnesota, United States
Immune Function after HCT
Incidence of neutrophil recovery
Time frame: 7 Years
Immune Function after HCT
Incidence of lymphocyte and monocyte subset recovery
Time frame: 7 Years
Immune Function after HCT
Incidence of grade II-IV acute GVHD
Time frame: 7 Years
Immune Function after HCT
Incidence of CMV reactivation
Time frame: 7 Years
Immune Function after Cell Therapy/Immunotherapy
Incidence of neutrophil recovery
Time frame: 7 Years
Immune Function after Cell Therapy/Immunotherapy
Incidence of lymphocyte and monocyte subset recovery
Time frame: 7 Years
Immune Function after Cell Therapy/Immunotherapy
Incidence of cytokine release syndrome (CRS)
Time frame: 7 Years
Correlate Immune Parameters
Correlate the lymphocyte phenotypes, specifically natural killer cell subsets and lymphocyte response to viral antigen.
Time frame: 7 Years
Correlate microbiota changes and their interactions with the host with outcomes of HCT
Correlate microbiota changes and their interactions with the host with outcomes of HCT
Time frame: 7 Years
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