Spanish Cohort of Patients with HIV Infection Older Than 50 Years for the Study of Fragility and Physical Function

To know the prevalence of frailty in the population over 50 years old with HIV infection according to Fried's fragility phenotype

Fragility is defined according to the 5 Fried criteria: * Involuntary weight loss: (\> 4.5Kg in the last year) * Declined mood: through two questions from the Scale for Depression of the Center for Epidemiological Studies (CES-D). * Speed of walking adjusted for height and sex, * Weekly physical activity adjusted by sex. * Muscle weakness according to manual grip strength adjusted for BMI and sex.

Time frame: Change from basal to year 5

Define a new simplified fragility index for the elderly patients with HIV infection easily applicable in clinical routine practice

The simplified fragility index for the elderly patient with HIV infection can not be defined a priori, so a multivariate logistic regression analysis will be performed for those variables that are associated with fragility in the analysis univariate, which will allow us to determine the variables that are associated in a independent with fragility, which will be with which we will define the fragility index simplified. Fragility will be treated as a binary variable: pre-fragile and robust will form a group that will serve as control. The fragility phenotype defined by the 5 Fried criteria will be considered the gold standard test to measure fragility when validating the simplified fragility screening test specific for elderly patients with HIV infection that we want to define

Time frame: Year 5

To study the prognostic value of the CD4 / CD8 ratio in relation to frailty

Time frame: Change from Basal to Year 5

Analyze the relationship between exposure time to different families of antiretroviral drugs with fragility.

Time frame: Change from Basal to Year 5

Define fragility biomarkers

immunological profile, oxidative damage, microbiome.

Time frame: Change from Basal to Year 5