Evaluation of Ocoxin®-Viusid® in Metastatic Colorectal Adenocarcinoma

Inclusion Criteria: * Patients of any sex, resident in Cuba, with an age greater than or equal to 18 years. * Patients that meet the diagnostic criteria. * Patients with general health according to Karnofsky ≥70%. * Life expectancy greater than or equal to 3 months. * Patients eligible to receive FOLFOX-IV chemotherapy. * Patients who have signed the informed consent. * Patients who have laboratory values in parameters that do not contraindicate the administration of chemotherapy: * Hemoglobin ≥ 90 g / l * Total Leukocyte Count ≥ 3.0 x 109 / L * Absolute Neutrophil Count ≥1.5 x 109 / L * Platelet Count ≥100 x 109 / L * Total bilirubin values ≤ 1.5 times the upper limit of the normal range established in the institution. * TGO and TGP values ≤2.5 times the upper limit of the normal interval established in the institution. * Creatinine values within the normal limits of the institution. Exclusion Criteria: * Pregnant or lactating patients. * Patients with known hypersensitivity to (5 Fluoracil, Folinic Acid or Oxaliplatin). * Patients who are receiving another product under investigation. * Patients with decompensated intercurrent diseases, including: hypertension, diabetes mellitus, ischemic heart disease, active infections, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, liver damage or any other special condition that at the discretion of the doctor puts their health at risk and his life during the study or his participation in the trial. * Patients with brain metastases. * Patients with mental disorders that may limit adherence to the requirements of the clinical trial and may hinder the collection of information, treatment or follow-up. It is planned to include a total of 40 patients in the study, taking into account 10% of losses.