Circulatory shocks (CS) are life-threatening, acute organ dysfunction. Advances in critical care medicine have decreased early hospital mortality, increasing the number of surviving patients. Regrettably, these survivors are at increased risk of new infections but also of cardiovascular disease. The investigators hypothesize that CS with multi-organ dysfunction is associated with premature senescence of endothelial cells and immune cells and promotes endothelial thrombogenicity and immunosenescence leading to cardiovascular disease and secondary infections. The aim of this work is therefore to evaluate the contribution of endothelial and leucocytes senescence to the occurrence of secondary events (infectious and cardiovascular) in patients with a CS. It will provide a better understanding of the pathogenesis of cardiovascular and immune diseases following a CS, likely to guide new management strategies to prevent their occurrence.
Study Type
OBSERVATIONAL
Enrollment
520
Noninvasive, reproducible, and sensitive methods to measure cardiac function, endothelial function, and arterial stiffness will be assess.
Hôpitaux Universitaires de Strasbourg - Service de Réanimation médicale du NHC
Strasbourg, France
RECRUITINGThe main criterion will be the acquisition of a senescent phenotype concerning leukocytes and endothelial cells.
Biological samples will be done to evaluate the endothelial and leukocyte senescence.
Time frame: 1 year
Incidence of cardiovascular events and secondary infection in hospitalized patients in intensive care unit for circulatory shock states
Time frame: 5 years
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