Hyperion Is A Prospective, Multicenter, Non-Interventional, Two-Cohort Study Collecting Primary Data In Patients With Locally Advanced Or Metastatic NSCLC Of Squamous Or Non-Squamous Histology After Prior Chemotherapy Being Treated With Atezolizumab In Routine Clinical Practice.
Study Type
OBSERVATIONAL
Enrollment
358
Atezolizumab will be administered per the Summary of Product Characteristics (SmPC) from the European Medicines Agency (EMA).
Time to loss of clinical benefit (TTLCB) from Atezolizumab treatment
Time frame: Time from first dose to loss of clinical benefit as assessed by the treating physician, through the end of study (approximately 5 years).
Duration of response (DOR) to Atezolizumab treatment
Time frame: Time from first documentation of complete response (CR) or partial response (PR), whichever occurs first, until progressive disease (PD), as evaluated by the physician according to routine practice or death; through the end of study (~ 5 years)
Disease control rate (DCR) of overall population
Time frame: Percentage of patients who achieved a CR, a PR, or stable disease (SD) as evaluated by the physician according to clinical practice at the time of the fifth Atezolizumab infusion; (until the end of study, approximately 5 years)
Progression-free survival (PFS) of overall population
Time frame: Time from initiation of study treatment to the first occurrence of progressive disease (PD) or death from any cause, whichever occurs first, as evaluated by the physician according to clinical practice, through the end of study (approximately 5 years)
Time to response (TTR) of overall population
Time frame: Time from first dose to first response as assessed in clinical routine, through the end of study (approximately 5 years)
Overall response rate (ORR) of overall population
Time frame: Rate of CR and PR in patients as assessed in clinical routine, through end of study (approximately 5 years)
Best overall response (BOR) of overall population
Time frame: Best response achieved within 12 weeks as assessed in clinical routine, through the end of study (approximately 5 years)
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Hämato-Onkologische Schwerpunktpraxis am Klinikum Aschaffenburg
Aschaffenburg, Germany
Studienzentrum Aschaffenburg
Aschaffenburg, Germany
Zentralklinikum Augsburg
Augsburg, Germany
Dres. Helmut Tanzer Joachim Hornberger und Johannes Kern
Bad Reichenhall, Germany
Klinikum Mittelbaden; Medizinisches Versorgungszentrum - Hämatologie und Onkologie
Baden-Baden, Germany
Sozialstiftung Bamberg, Klinikum am Bruderwald, Gynäkologie
Bamberg, Germany
St. Hedwig Kliniken Berlin GmbH
Berlin, Germany
Onkologisches Versorgungszentrum Friedrichshain; Hämatologie, Onkologie und Palliativmedizin
Berlin, Germany
Praxis Dr. Med. Gunhild Kühn
Berlin, Germany
Onkologie am Segelfliegerdamm
Berlin, Germany
...and 84 more locations
Best overall response of patients in cohort 2 ("Coh2 BOR")
Time frame: Baseline through the end of study (approximately 5 years)
Overall survival of cohort 2 ("Coh2 OS")
Time frame: Time from initiation of Atezolizumab treatment to death from any cause (until the end of study, approximately 5 years).
Percentage of participants with Adverse Events (AEs)
Time frame: Baseline through the end of study (approximately 5 years)