Optimization of PK/PD Target Attainment for Meropenem in Critically Ill Patients With Sepsis

Universitaire Ziekenhuizen KU Leuven116 enrolled

Overview

WP1.1. PK/PD target attainment: Plasma exposure, Excretion via urine \& ELF exposure; WP1.2. Predictive dosing algorithm; WP1.3. ECMO subset

First, the investigators will document exposure to meropenem in plasma and epithelial lining fluid. Moreover excretion in urine will be documented. Second, the investigators will try to identify risk factors for not attaining PK/PD target. Based on significant predictors for target non attainment a predictive dosing algorithm will be constructed. Finally in a small subset of ECMO patients PK exposure will be explored.

Study Type

OBSERVATIONAL

Enrollment

116

Conditions

Critical Illness Pharmacokinetics

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Severe sepsis or septic shock * Admitted to an ICU ward * Treated with meropenem Exclusion Criteria: * eGFR(CKD-EPI) \< 70ml/min/1.73m² * Renal replacement therapy * Pregnancy * DNR code 1-3

Outcomes

Primary Outcomes

Risk factors for target non attainment

risk factors will be assessed by comparing patients who attain target vs. those who don't

Time frame: on day of sampling

Data from ClinicalTrials.gov

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