Comparisons of Urodynamic, Bladder Diary, Quality of Life Parameters Between OAB-wet and OAB-dry Female Patients

National Taiwan University Hospital623 enrolled

Overview

A small bladder capacity and more frequent urgency episodes were predictors of OAB-wet, and the above findings might indicate that OAB-wet and OAB-dry are a continuum of OAB. Older age, high maximum flow rate, high detrusor pressure at maximum flow rate and the presence of urodynamic stress incontinence were also independent predictors for OAB-wet, and the above might indicate that OAB-wet and OAB-dry have at least partly different underlying pathophysiologies.

Aims: To identify factors predicting the presence of OAB-wet and to further derive the underlying pathophysiology in OAB-wet vs. OAB-dry. Methods: Between September 2007 and September 2013, the medical records of women with OAB who completed a 3-day bladder diary and underwent urodynamic studies in a tertiary referral center will be reviewed. OAB-wet will be diagnosed in patients who complained of at least one episode of urgency incontinence in the previous month; otherwise, OAB-dry is diagnosed. Multivariate logistic regression analysis will be used to predict the presence of OAB-wet.

Study Type

OBSERVATIONAL

Enrollment

623

Conditions

Urinary Bladder, Overactive

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 99 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. The diagnosis of overactive bladder disease 2. Female patient of more than 20 year-old Exclusion Criteria: 1. Dominant symptoms with stress urinary incontinence (SUI) 2. Regular urethral catheterization or intermittent self-catheterization 3. Urinary tract infection or chronic inflammation in the previous 2 weeks 4. Bladder calculus 5. A history of pelvic radiotherapy 6. A preexisting malignant pelvic tumor.

Outcomes

Primary Outcomes

Compare the difference of urodynamic parameters between OAB-wet and OAB-dry

The variables of urodynamic study included maximum flow rate, average flow rate, voided volume, volume of strong to desire, detrusor pressure at maximum flow during voiding cystometry (PdetQmax), Valsalva leak point pressure (VLPP), maximal urethral pressure (MUP), maximal urethral closure pressure (MUCP), functional profile length, urethral closure pressure area (UCPA), continence length, continence area, pressure transmission ratio (PTR) at MUP, and electromyography (EMG). The urodynamic parameters will be interpreted together to get a complete urodynamic report and diagnosis, thus to compare the difference between OAB-wet and OAB-dry

Time frame: 1 week

Compare the difference of bladder diary parameters between OAB-wet and OAB-dry

The 3-day bladder diary parameters included maximum daytime voided volume excluding the morning void derived from 3-day bladder diaries (DVVmax), urgency episodes, urgency incontinence episodes, daytime frequency, nocturia, total voided volume and total water intake. The bladder diary parameters will be interpreted together to get a complete report, such as urinary urgency and nocturia, thus to compare the difference between OAB-wet and OAB-dry

Time frame: 1 week

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.