Comparing the Franseen and Fork-top Needles for EUS-guided Fine-needle Biopsy of Solid Mass Lesions.

Inclusion Criteria: * Subjects from any ethnic background * Successfully completes the screening process * Has signed written informed consent by patient or surrogate * Demonstrate willingness to follow protocol requirements, including follow-up schedule, and completion of study questionnaires. * Patients must have evidence of a lesion seen on endoscopic ultrasound that is accessible * Lack of severe or terminal co-morbidity, as judged by the generalists or specialists caring for the patient. Exclusion Criteria: * History of allergic reaction of hypersensitivity to the medications / anesthesia. * Female participants of childbearing age who are pregnant * Female participants who are breastfeeding. * Participant has history of significant cardiovascular or pulmonary disease (e.g., myocardial infarct, unstable angina, congestive heart failure, arrhythmia, pulmonary edema or COPD), or other significant cerebrovascular disease (stroke) * Patients who are uncooperative, unable to give written informed consent, who cannot return for follow-up, or refuse informed consent * Persistent shock or hypertension (e.g., systolic blood pressure less than or equal to 99 mm mercury) that is unresponsive to less than or equal to 6 units of packed red blood cell (RBC) transfusions or requires continuous intravenous infusions of vasoactive drugs for blood pressure elevation. * Severe coagulopathy unresponsive to blood transfusions (e.g., international normalized ratio \>2.0, platelet count \<20,000. activated partial thromboplastin time greater than 2.0 x normal, or bleeding time \> 10 minutes) * Contraindication to urgent endoscopy or follow-up procedures or inaccessible due to altered anatomy, moderate / tense ascites. * Participant has uncontrolled diabetes / uncontrolled hypertension / severe immunodeficiency.