Effects of Xanthohumol on Metabolic Syndrome Progression

Inclusion Criteria: * Men and women, 25-65 years of age; * Criteria for metabolic syndrome according to the 2005 revised NCEP ATP III guidelines: * HDL-C \< 40 mg/dL ♂ and \< 50 mg/dL ♀; * Triglycerides ≥ 150 mg/dL; * Blood pressure ≥ 130/85 mmHg; * Fasting plasma glucose ≥ 100 mg/dL; * Waist circumference ≥ 102 cm ♂ and ≥ 88 cm ♀; * HbA1c 5.8/6.0-6.4; * Nonsmokers or no other tobacco use in the last 3 months; * Willing to stop taking regular supplements including antioxidants for 2 weeks prior to study entry through conclusion of study; * Willing to stop consumption of beer for 2 weeks prior to study entry through conclusion of study; * Must be able to provide informed consent; * Blood screen tests \[comprehensive metabolic panel (CMP), and lipid profile\] within normal limits or if outside normal limits, approved for participation at the discretion of the study physician. Exclusion Criteria: * Have a significant acute or chronic coexisting illness, such as cardiovascular disease, chronic kidney or liver disease, gastrointestinal disorder, endocrine disorder, immunological disorder, metabolic disease, cancer, chemotherapy history, gluten intolerance, eating disorders, depression or any psychiatric condition, diabetes, or any condition which contraindicates entry in the study, according to the investigators' judgment; * Currently taking prescription drugs other than oral contraceptives (over-the-counter medications are allowed upon review and discretion of the study physician); * Consumption of more than the recommended alcohol guidelines (\> 1 drink/day ♀ and \> 2 drinks/day ♂); * Consumption of high levels of beer; * Pregnancy (as confirmed by urine pregnancy test) or planning to become pregnant before completing the study; * Breastfeeding; * Under UV therapy (e.g. psoriasis treatment), using UV tanning beds and unprotected sun exposure greater than 1 hour/day; * Engaging in vigorous exercise more than 6 hours/week; * Participation in other dietary study in the past 3 months; * Had surgery in the last 3 months; * Post-menopausal status.