Prevalence and Predictors of Proton Pump Inhibitor Partial Response in Gastroesophageal Reflux Disease in Systemic Sclerosis

The proportion of participant with diffuse cutaneous SSc (dcSSc) subset between the patient who response to omeprazole and partial response to omeprazole,

The number of dcSSc subset in the patient who response to omeprazole and partial response to omeprazole, DcSSc is defined as yes or no when the patient has skin tightness includes trunk and both extremities and not include trunk and extremities, respectively.

Time frame: 4 weeks

The proportion of participant with esophageal dysphagia between the patient who response to omeprazole and partial response to omeprazole,

The number of dysphagia in the patients who response to omeprazole and partial response to omeprazole. Esophageal dysphagia is defined as yes or no when the patients has dysphagia and no dysphagia symptom, respectively.

Time frame: 4 weeks

The proportion of participant with female gender between the patient who response to omeprazole and partial response to omeprazole

The number of female gender in the patients who response to omeprazole and partial response to omeprazole. Female gender is defined as yes or no when the patient is female and male, respectively.

Time frame: 4 weeks

The proportion of participant with age>60 years between the patient who response to omeprazole and partial response to omeprazole

The number of age\>60 years in the patients who response to omeprazole and partial response to omeprazole. Age\>60 is defined as yes or no when the patient has age\>60 and equal or less than 60 years, respectively.

Time frame: 4 weeks

The proportion of participant with modified Rodnan skin score (mRSS)>20 between the patient who response to omeprazole and partial response to omeprazole

The number of mRSS\>20 in the patients who response to omeprazole and partial response to omeprazole. The mRSS was assessed at 17 sites; viz., the face, chest, abdomen, arms, forearms, hands, fingers, thighs, legs and feet. Assessment was rated as 0 (normal skin thickness), 1 (mild but definite skin thickness), 2 (moderate thickness), or 3 (sever thickness with inability to pinch a fold of skin). The score was calculated by summing the rating score from all 17 areas (range, 0-51). mRSS\> 20 is defined as yes or no when the patient has mRSS\>20 and equal or less than 20, respectively.

Time frame: 4 weeks

The proportion of participant with serum anti-topoisomerase I antibody positive between the patient who response to omeprazole and partial response to omeprazole

The number of anti-topoisomerase I positive in the patients who response to omeprazole and partial response to omeprazole. Serum anti-topoisomerase I antibody is defined as yes or no when the antibody in serum was positive and negative, respectively.

Time frame: 4 weeks