A Pharmacokinetic Study to Assess Drug-drug Interaction Between Zanubrutinib and a Cocktail of Substrates in Healthy Subjects

Inclusion Criteria: All Groups * Male subjects in good health as determined by past medical history, physical examination, vital signs, ECG and laboratory tests at screening. * Subjects must have a body mass index (BMI) between 18 and 32 kg/m2. * Male subjects must agree to a highly effective method of birth control from screening until at least 90 days after the last dose of study drug. Exclusion Criteria: * Subjects with a clinically relevant history or presence of any clinically significant disease. * History of stomach or intestinal surgery or resection that would potentially alter absorption and/or excretion of orally administered drugs (uncomplicated appendectomy, cholecystectomy, and hernia repair will be allowed). * History of drug or alcohol abuse within 2 years prior to Check-In. * Alcohol consumption of \>21 units per week. * A positive urine drug screen and/or positive alcohol breath test at Screening and/or Check-in. * A positive Hepatitis B surface antigen (HBsAg) or Hepatitis C test result and/or a positive human immunodeficiency virus (HIV) at screening. * Use of tobacco- or nicotine-containing products within 3 months prior to Check-In. * History of blood donation of 56 days prior to Screening, plasma from 2 weeks prior to Screening, or platelets from 6 weeks prior to Screening.