The overall incidence of DWI positive for thromboembolic events following endovascular treatment of intracranial aneurysms is proximately 50%. Whether remote ischemic conditioning was safe and effective to reduce ischemic brain lesions on DWI after endovascular treatment of intracranial aneurysms is still unclear. The investigators' hypothesis is that remote ischemic conditioning is a safe and effective strategy to reduce new ischemic lesions in intracranial aneurysms patients undergoing endovascular treatment.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
210
Remote ischemic conditioning is performed by using an electric autocontrol device with cuffs that inflated to a pressure of 200 mm Hg during the ischemic period (Patent No. CN200820123637.X, China)
Sham remote ischemic conditioning is performed by using an electric autocontrol device with cuffs that inflated to a pressure of 60 mm Hg
Xuanwu Hospital, Capital Medical University
Beijing, Beijing Municipality, China
NOT_YET_RECRUITINGShengli Oilfield Central Hospital
Dongying, Shandong, China
RECRUITINGThe Second People's Hospital of Liaocheng
Liaocheng, China
RECRUITINGNanyang City Center Hospital
Nanyang, China
RECRUITINGThe First Affiliated Hospital of Zhengzhou University
Zhengzhou, China
RECRUITINGThe presence of ≥1 new brain lesions on DWI
Assessed by DWI
Time frame: within 72 hours after endovascular treatment
Number of new ischemic lesions
Time frame: within 72 hours after endovascular treatment
Volume of new ischemic lesions
Time frame: within 72 hours after endovascular treatment
National Institutes of Health Stroke Scale
Scores on the National Institutes of Health Stroke Scale (NIHSS) range from 0 to 42, with higher scores indicating more severe neurologic deficits.
Time frame: 7 days or discharge
Composite of Cerebrovascular events
This is a composited endpoint.Cerebrovascular events included ischemic stroke, hemorrhagic stroke, and TIA. The present subarachnoid hemorrhage isn't included.
Time frame: 30 days
Nondisabling events
Scores on the National Institutes of Health Stroke Scale (NIHSS) range from 0 to 42, with higher scores indicating more severe neurologic deficits.National Institutes of Health Stroke Scale ≤3 or TIA is defined as nondisabling events The present subarachnoid hemorrhage isn't included.
Time frame: 30 days
Modified Rankin Scale
Scores on the modified Rankin scale of functional disability range from 0 (no symptoms) to 6 (death).
Time frame: 30 days
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