Adult individuals with ulcerative colitis in remission are given a single fecal microbiota transplantation (FMT) in colonoscopy. A half of the patients will receive autologous FMT as a placebo and a half will receive an FMT from a healthy donor.
80 adult patients with ulcerative colitis (UC) will be recruited. They are randomized to receive either an autologous FMT as a placebo or FMT from a healthy donor (frozen and thawed). The patients are followed up with fecal samples to detect microbial changes. The follow up lasts 1 year after the FMT and a follow up colonoscopy will be done 52 weeks after the FMT.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
48
FMT administered into the cecum of the patient in colonoscopy.
Autologous FMT (fecal suspension made of patients own feces) administered into the cecum of the patient in colonoscopy.
Helsinki University Hospital
Helsinki, Finland
Päijät-Häme Central Hospital
Lahti, Finland
Maintenance of remission of ulcerative colitis
Endoscopic remission and Mayo-score \< 2
Time frame: 52 weeks
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