To investigate in vitro the effect of triglyceride rich lipoproteins (TGRL) obtained in type 2 diabetic women in the fasting state and following a randomized isocaloric lipid rich breakfast on control human platelets Randomized Comparison of butter versus chocolate spread in 2 groups of 15 patients
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
32
ingestion of proteins : 5 g, lipids 20 g, glucides 57 g
ingestion of proteins 7 g, lipids 20 g, glucides 56 g
Hôpital Louis Pradel - department of endocrinology
Bron, France
fasting thromboxane B2 concentration
ex vivo experiment : TGRL obtained by preparative Unesterified cholesterol (UC) incubated with control human platelets
Time frame: Hour 0
after breakfast thromboxane B2 concentration
ex vivo experiment : TGRL obtained by preparative Unesterified cholesterol (UC) incubated with control human platelets
Time frame: 4 hours
measurement of fasting platelet activation by turbidimetric method
Time frame: Hour 0
measurement of post prandial platelet activation by turbidimetric method
Time frame: 4 Hours
fasting lipidomic composition of triglyceride rich lipoproteins
Characterization and comparison of LRT lipidomics in fasting DT2 patients and following the ingestion of a high-fat breakfast according to their source (short and medium chain fatty acids (butter) versus palmitic acid (palm oil present in spreads).
Time frame: Hour 0
post prandial lipidomic composition of triglyceride rich lipoproteins
Characterization and comparison of LRT lipidomics in fasting DT2 patients and following the ingestion of a high-fat breakfast according to their source (short and medium chain fatty acids (butter) versus palmitic acid (palm oil present in spreads).
Time frame: 4 Hours
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.