This is a longitudinal, observational study with the aims of comparing spinal cord gray matter areas in patients with Post-Polio Syndrome to age and sex matched healthy control subjects and to correlate atrophy with metrics of clinical disability.
Post-Polio syndrome (PPS) is characterised by new muscle weakness, pain, and fatigue several years to decades after the acute polio infection. Pathomechanisms are not yet fully understood. This is a longitudinal, observational study. The aims are (a) to detect spinal cord gray (and possibly) white matter atrophy in patients with Post Polio Syndrome in comparison to healthy age and sex matched control subjects both cross-sectionally and longitudinally and (b) to correlate spinal cord gray and white matter atrophy to metrics of clinical disability. Investigators will assess 20 patients with Post-Polio syndrome and 20 control subjects at baseline and 48 weeks by MRI and clinically including quantitative muscle strength assessments.
Study Type
OBSERVATIONAL
Enrollment
40
MRI of spinal cord and brain
quantitative assessment of muscle force
University Children's Hospital Basel
Basel, Canton of Basel-City, Switzerland
spinal cord gray matter (GM) area measured by MRI
Change in spinal cord cross-sectional gray matter area measured at baseline and at year 1
Time frame: change between baseline and year 1
spinal cord white matter (WM) area measured by MRI
spinal cord cross-sectional white matter area
Time frame: at baseline
change in spinal cord white matter (WM) area measured by MRI
Change spinal cord cross-sectional white matter area
Time frame: between baseline and year 1
total spinal cord area measured by MRI
spinal cord total cross-sectional area
Time frame: at baseline
Change in total spinal cord area measured by MRI
Change in spinal cord total cross-sectional area
Time frame: between baseline and year 1
quantitative muscle strength measured by hand-held dynamometer
assessed by hand-held dynamometer
Time frame: at baseline
change in quantitative muscle strength measured by hand-held dynamometer
assessed by hand-held dynamometer
Time frame: between baseline and year 1
motor cortical thickness measured by MRI
motor cortical thickness
Time frame: at baseline
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Change in motor cortical thickness measured by MRI
Change in motor cortical thickness
Time frame: between baseline and year 1