The CMUBCS is a birth cohort study located in Shenyang, China. Its initial aim is to facilitate research on understanding the interplay between genes and environmental factors on disease etiology. Data are collected regarding environmental factors, family and lifestyle, clinical experimental outcomes and imaging results of pregnant women and children from birth to 18 years old. Biological samples including blood and tissue samples are also collected from the children and their parents.
Early life phase (fetal and infant) is a critical period for the development of health and disease in a person's life. Many adult chronic diseases, such as diabetes, cardiovascular and cerebrovascular diseases, all come from the exposure of negative environmental and behavioral factors during this period. By collecting the lifestyle data and clinical data of pregnant women at different periods, the appropriate indicators are anticipated to be selected to predict and evaluate the outcome of pregnancy and the health of the mothers and children in the long term. The status of overweight and obesity of children in Shenyang and its surrounding areas are anticipated to be analyzed by descriptive and etiological analysis through collecting the lifestyle data and clinical data of different periods of pregnant women and the lifestyle data of different developmental stages of children.
Study Type
OBSERVATIONAL
Enrollment
1,000
Shengjing Hospital
Shenyang, Liaoning, China
RECRUITINGChange of biometric parameter in centimeter of fetuses at the thirteenth week of gestational age
Including head circumference, abdominal circumference, biparietal diameter, femur length of singleton and twin pregnancy
Time frame: At every week from the thirteenth week of gestational age to delivery of babies
Weight in kilogram of neonate
Including singleton and twin pregnancy measured by nurses
Time frame: At birth of neonate
Gene expression of husbands of pregnancy women
DNA methylation, histone acetylation etc. assessed by analyses of blood
Time frame: At 13 weeks of gestational age
Change of gene expression of pregnancy women
DNA methylation, histone acetylation etc. assessed by analyses of blood
Time frame: At 13, 26 and 34 weeks of gestational age
Result of Non-invasive Prenatal Testing
including singleton and twin pregnancy
Time frame: From 12 to 22 weeks of gestational age
Change of intestinal flora during early childhood
Assessed by analyses of stool samples
Time frame: Age at 1 year, 3 years, 6 years, 9 years, 12 years, 15 years and 18 years
Height in centimeter changes during childhood
Measured by nurses in clinic
Time frame: Age at 1 year, 3 years, 6 years, 9 years, 12 years, 15 years and 18 years
Weight in kilogram changes during childhood
Measured by nurses in clinic
Time frame: Age at 1 year, 3 years, 6 years, 9 years, 12 years, 15 years and 18 years
Change of gene expression during childhood
DNA methylation, histone acetylation etc. assessed by analyses of blood
Time frame: Age at 1 year, 3 years, 6 years, 9 years, 12 years, 15 years and 18 years
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