microRNAs Role in Pre-eclampsia Diagnosis

Cairo University200 enrolled

Overview

Pre-eclampsia is one of the most threatening pregnancy complications. So far neither a secure, competent therapy for PE nor effective biomarkers for a premature discovery has been achieved.The aim of our study was to identify miRNAs 136, 494 and 495 genes expression in exosomes of peripheral blood compared to umbilical cord mesenchymal stem cells conditioned media released exososomes in patients with PE, as valuable markers for PE early prediction.

Study Type

OBSERVATIONAL

Enrollment

200

Conditions

Preeclampsia

Eligibility

Sex: FEMALEMin age: 23 YearsMax age: 35 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: To have an uncomplicated pregnancy: 1. gestational age at venipuncture between 20 - 42 weeks 2. no medical, obstetrical, or surgical complications 3. absence of labor at the time of venipuncture 4. delivery of a normal term (≥ 37 weeks) neonate whose birth weight was between the 10th and 90th percentile for gestational age Exclusion Criteria: Patients with chronic hypertension, renal disease, and fetuses affected with congenital anomalies were excluded

Outcomes

Primary Outcomes

The expression of miRNAs 136, 494 and 495 in exosomes of peripheral blood and UCMSCs conditioned media

Time frame: 2-3 months

Data from ClinicalTrials.gov

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