Control Trial of Intermittent Hemodialysis With Regional Citrate VS Priming Heparin With Predilution in Patients at Risk of Bleeding

Inclusion Criteria: * The patient has been correctly informed. * The patient must have given his/her informed and signed consent. * The legal guardian or trusted-person of an adult under guardianship must have given their informed and signed consent. * The patient has health insurance coverage via the French social security system. * The patient is at least 18 years old. * The patient is at bleeding risk; the bleeding risk is defined by the clinical situation and according to predefined clinical situations (before or after surgery or biopsy, hemorrhage). * The patient requires an intermittent hemodialysis in a nephrology ICU setting. Exclusion Criteria: * The patient is participating in, or has participated in over the past three months, another interventional trial. * The patient is in an exclusion period determined by a previous study. * The patient is under judicial protection. * The parents (or legal guardian) of the patient refuse to sign the consent. * It is impossible to correctly inform the patient/parents (or legal guardian) of the patient (language barrier). * Contraindication to heparin treatment. * Indication of continuous dialysis in ICU. * Pregnancy.