Lactated Ringer(LR) has been extensively used to maintain and replace intravascular volume in a variety of anesthetic procedures. However, the utility of LR in pediatric with hepatic failure undergoing liver transplantation is unclear, because addition of exogenous lactate may increase lactate concentration. In addition,large amounts of normal saline(NS) which does not contain lactate can induce a hyperchloremic metabolic acidosis and have been asociated with adverse effects on kidney injury, coagulation, and death. Accordingly, the investigators performed a double-blinded randomized trial comparing the effects of intraoperative NS or LR on outcomes in pediatric receiving Liver transplantation.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
200
Patients will be administered Lactated Ringer's solution for intraoperative fluid management.
Patients will be administered normal saline for intraoperative fluid management.
Renji Hospital
Shanghai, Shanghai Municipality, China
RECRUITINGChange in lactate level of the lactated ringer group compared to the normal saline group
Baseline serum lactate will be measured after randomization and again after surgery, then every 24 hours for 72 hours
Time frame: up to 3 days after surgery
Length of mechanical ventilation
Length of mechanical ventilation in ICU measured in hours
Time frame: up to 30 days after surgery
ICU stay
Days spend in ICU within 30 days
Time frame: up to 30 days after surgery
30 day mortality
Patient mortality during the first 30 days after surgery
Time frame: up to 30 days after surgery
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.