Efficacy and Safety of Vildagliptin Added to Continuous Subcutaneous Insulin Infusion in Uncontrolled Type 2 Diabetes

Inclusion Criteria: * T2DM * 30≤ age≤70 years old * BMI 18.0-28.0 Kg/m2 * HbA1c ≥8.5% * Negtive GAD、ICA、IAA * Patients do not use antihyperglycemia drugs * Patients use antihyperglycemia drugs for ≥8 weeks(exclusion of DPP-4 inhibitors and GLP-1 receptor agonist) Exclusion Criteria: * T1DM,GDM * Congestive heart failure (New York Heart Association Functional Classification III-IV) * ALT or AST\> 2 times above normal,GFR \<50ml/min * Severe infection in the previous 3 months * Severely acute or chronic diabetic complications * Patients who were taking medications,known to affect glycaemic control, such as glucocorticoids(aside from antidiabetic medications) * History of pancreatitis * Trauma or patients operating at a scheduled time * Any mental health condition