The purpose of this study is to investigate if the blood levels of experimental medication BMS-986224 will be changed when given together with Rifampin, an antibiotic that affects specific enzymes involved with the breakdown of BMS-986224.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
42
Specified dose on specified days
Specified dose on specified days
PRA Health Sciences
Salt Lake City, Utah, United States
Maximum observed plasma concentration (Cmax) of BMS-986224
Time frame: 5 days
Area under the plasma concentration-time curve from time zero to time of last quantifiable concentration [AUC(0-T)] of BMS-986224
Time frame: 5 days
Area under the plasma concentration-time curve from time zero extrapolated to infinite time [AUC(INF)] of BMS-986224
Time frame: 5 days
Biomarker plasma concentrations of BMS-986224
Time frame: 5 days
Time of maximum observed plasma concentration (Tmax) of BMS-986224
Time frame: 5 days
Terminal elimination half-life (T-HALF) of BMS-986224
Time frame: 5 days
Metabolite of BMS-986224 Cmax
Time frame: 5 days
Metabolite of BMS-986224 AUC(0-T)
Time frame: 5 days
Metabolite of BMS-986224 AUC(INF)
Time frame: 5 days
Incidence of nonserious adverse events (AE)
Time frame: 17 days
Incidence of serious adverse events (SAE)
Time frame: 30 days
Incidence of AEs leading to discontinuation
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Time frame: 17 days
Composite results of vital signs, electrocardiograms, physical examinations,and clinical laboratory tests
Time frame: 18 days