Abnormal body composition with increased body fat mass and decreased lean body mass has been found in adults with Prader-Willi syndrome (PWS), contributing to reduced physical capacity and impairment. The aim of this study was to investigate whether progressive elastic band resistance training can improve physical motor performance and regional body composition in adults with PWS.
Six participants were enrolled in this pilot study. Following 24 weeks of progressive elastic band resistance exercise training, significant reduction was observed in their body weight, BMI, and regional extremities fat mass and percentage. Regarding the functional performances, there were also significant improvements in their hand grip strength, 3 meter timed up and go, 30 seconds sit to stand, and 2-min step up tests, as early as the 8th week of training. Balance function achieved significant improvements after 16 weeks of training.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
6
PWS participants received 9 sets exercises for the major muscle groups, over 24 weeks, three times a week, for a total of 72 sessions.
Changes in the handgrip strength functional physical assessment
hand grip strength (pounds),
Time frame: Changes from Baseline functional motor performance tests at 8 weeks, 16 weeks and 24 weeks
Changes in the 30 second chair stand functional physical assessment
30-second chair stand test (times)
Time frame: Changes from Baseline functional motor performance tests at 8 weeks, 16 weeks and 24 weeks
Changes in the timed up and go functional physical assessment
timed up-and-go test (seconds)
Time frame: Changes from Baseline functional motor performance tests at 8 weeks, 16 weeks and 24 weeks
Changes in the two minute step up functional physical assessment
2 minute step up test (times)
Time frame: Changes from Baseline functional motor performance tests at 8 weeks, 16 weeks and 24 weeks
Changes in the balance functional physical assessment
Berg Balance Scale (0-56 points; 0-20= high fall risk; 21-40= medium fall risk; 41-56= low fall risk)
Time frame: Changes from Baseline functional motor performance tests at 8 weeks, 16 weeks and 24 weeks
Change in the BMI body composition
Body weight (km) and height (m) will be combined to report as BMI (kg/m2)
Time frame: Change from Baseline body composition components at 6 months
Change in the percentage of body fat of body composition
Regional percentage body fat (%)
Time frame: Change from Baseline body composition components at 6 months
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Change in the body fat mass of body composition
Fat mass (kg)
Time frame: Change from Baseline body composition components at 6 months
Change in the lean body mass of body composition
Lean body mass (kg)
Time frame: Change from Baseline body composition components at 6 months