Pneumococcal Vaccination to Accelerate Immune Recovery in Sepsis Survivors

Inclusion Criteria: Patients who meet all the following inclusion criteria are eligible to participate in the trial. * Male or female adult patients aged 18 years or older on the date of screening for the trial * Registered with a General Practitioner * Reason for admission to intensive care unit or high dependence unit (HDU) was sepsis * Clinical condition has improved and the patient is ready for step down to HDU or ward based care in the next 24 - 48 hours * Provision of written informed consent by the patient OR by patient's Legal Representative OR Professional Consultee. Exclusion Criteria: Patients who meet one or more of the following will be excluded from the trial. * Core temperature ≥38.0°C within the past 24 hours prior to study IMP administration. As with other vaccines, the administration of Prevenar 13 should be postponed in subjects suffering from acute, severe febrile illness. However, the presence of a minor infection, such as a cold, should not result in the deferral of vaccination. * Hypersensitivity reaction (e.g., anaphylaxis) to any component of Prevenar 13 or any diphtheria toxoid-containing vaccine. * Recent vaccination defined as any vaccination administered to subjects within 7 days of enrolment. * Pregnant and lactating women. * Limitations of care set including not for resuscitation, not for readmission to critical care. * Residence in a nursing home, long-term care facility, or other institution, or requirement of semiskilled nursing care. (An ambulatory subject who was a resident of a retirement home or village is eligible for the trial.) * As the IMP is administered intra muscularly, coagulopathy defined as platelet count less than 50 x 109/L and/or International Normalized Ratio (INR) greater than 1.3. For this exclusion criteria bloods taken within 72 hours of screening are valid. If these standard of care blood results are not available, then these should form part of the screening bloods for assessing eligibility. * Splenectomy (previous or in the current admission) * Diagnosis of pneumococcal sepsis in the current admission * APACHE II score defined Immune deficiency or suppression, defined as presence of 1 or more of the following conditions: * Documented human immunodeficiency virus (HIV) infection at any time-point pre-trial. If previous results are not available and/or current admission is not due to HIV infection, these patients do not need new testing and are considered eligible for the trial. * leukaemia (presence defined as having been treated by or been eligible for treatment by radiotherapy and/or chemotherapy within the last 5 years) * lymphoma (presence defined as having been treated by or been eligible for treatment by radiotherapy and/or chemotherapy within the last 5 years) Hodgkin disease (presence defined as having been treated by or been eligible for treatment by radiotherapy and/or chemotherapy within the last 5 years) * multiple myeloma (presence defined as having been treated by or been eligible for treatment by radiotherapy and/or chemotherapy within the last 5 years) * malignancy (defined as presence of any malignancy that had been treated by or had been eligible for treatment by radiotherapy and/or chemotherapy within the last 5 years) * chronic renal failure (defined as receipt of renal dialysis or transplant) or nephrotic syndrome * receipt of immunosuppressive therapy, including steroids, within 3 months of study vaccine administration (For corticosteroids, prednisone or equivalent 0.5 mg/kg/day for 14 days or longer. Inhaled, intra- articular, and topical steroids are not considered immunosuppressive). * Receipt of an organ or bone marrow transplant with ongoing immunosuppressive medications. Failed previous transplant patients not currently on immunosuppression are eligible.