Beta2-adrenergic Agonism and Muscle Remodelling

Morten Hostrup, PhD72 enrolled

Overview

The study aims to investigate gender-specific adaptations to beta2-adrenoceptor stimulation with selective short- and long-acting beta2-agonist with emphasis on skeletal muscle in relation to performance enhancing effects and anti-doping

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

TRIPLE

Enrollment

Conditions

Hypertrophy Physiologic Hypertrophy Physical Activity

Interventions

FormoterolDRUG

Subjects are treated with daily inhalation of formoterol

TerbutalineDRUG

Subjects are treated with daily inhalation of terbutaline

PlaceboOTHER

Subjects are treated with placebo

Eligibility

Sex: ALLMin age: 18 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy men and women, aged 18-45 years * VO2max \>55 ml/kg/min for men and \>50 ml/kg/min for women (± biologic and techinical variation of 5.6% (Katch et al. 1982) * Body Mass Index (BMI) \< 26 Exclusion Criteria: * Chronic user of beta2-agonist or allergy towards study drugs * Serious adverse side effects of the used study drug * Chronic disease that by the project physician would affect any of the outcomes of the study * Smoker * Chronic use of prescription medication (other than contraceptives for women) * Pregnancy

Locations (1)

August Krogh Building

Copenhagen, Denmark

RECRUITING

Outcomes

Primary Outcomes

Proteome enrichment

Change in enrichment (measured in muscle biopsies and assessed using GO annotations)

Time frame: Baseline and 6 weeks

Secondary Outcomes

Body composition

Change in body composition (measured by dual energy x ray absorptiometry)

Time frame: Baseline, 2 weeks, 4 weeks and 6 weeks

Maximal oxygen consumption (VO2max)

Change in VO2max (measured during bike ergometer cycling to exhaustion)

Time frame: Baseline, 2 weeks, 4 weeks and 6 weeks

Data from ClinicalTrials.gov

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