Along with population ageing, the association of chronic conditions such as Alzheimer's Disease and Related Syndromes (ADRS) and diabetes mellitus is increasing in clinical practice. According to ADRS severity, guidelines of diabetes care may be adapted for a personalized monitoring and treatment. The consequences on diabetes complications are not known and can also threaten dementia progression. Based on a nationwide healthcare reimbursement database, the present study aimed to compare diabetes care and the incidence of acute complications between patients with or without ADRS, in a longitudinal perspective focusing on the pivotal period of ADRS identification by the healthcare system.
Study Type
OBSERVATIONAL
Enrollment
87,816
Incidence analysis between the 2 groups (ADRS/non ADRS). For each pair, an index date was defined as the ADRS identification date. In both groups, a 5-year period free of these three ADRS criteria was required before the index date, to ensure incident ADRS cases.
University Hospital
Toulouse, France
Diabetes control
Given the absence of consensual guidelines describing the frequency of diabetes monitoring among elderly subjects, we defined a conservative minimal threshold as follows: ambulatory biological monitoring : * ≥ 1 annual HbA1c determination (primary endpoint) * ≥ 2 annual HbA1c determination * ≥ 1 annual lipid profile (≥ 1 annual LDL cholesterol, ≥ 1 annual triglyceride)
Time frame: one year
Ocular Diabetes complications
≥ 1 annual eye examination, defined by a visit to an ophthalmologist or a dilated fundus examination, in or out of the hospitals
Time frame: one year
Hypoglycemia
≥ 1 annual hospitalization for hypoglycemia
Time frame: one year
ketoacidosis without coma
≥ 1 annual hospitalization for ketoacidosis without coma
Time frame: one year
diabetic coma
\- ≥ 1 annual hospitalization for diabetic coma (with ketoacidosis, hyperosmolar or hypoglycemia)
Time frame: one year
diabetic nephropathy
≥ 1 annual hospitalization for diabetic nephropathy
Time frame: one year
diabetic neuropathy
≥ 1 annual hospitalization for diabetic neuropathy
Time frame: one year
hospitalization for any of the 5 previous diabetes-related cause
≥ 1 annual hospitalization for any of the 5 previous diabetes-related cause
Time frame: one year
hospitalization for falls and femoral fracture
≥ 1 annual hospitalization for falls and femoral fracture
Time frame: one year
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.