Magnesium Sulphate Versus Lidocaine for Control of Emergence Hypertension

Ahmed Mohamed ELbadawy90 enrolled

Overview

Post-craniotomy emergence hypertension is a common phenomenon that may predispose to development of intracranial hematoma and cerebral edema.The aim of this study is to compare the safety and efficacy of Mgso4 versus lidocaine infusion for control of emergence hypertension after craniotomy.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Craniotomy Hypertension

Interventions

Magnesium sulphateDRUG

Magnesium sulphate 50 mg/kg over 10 minutes loading followed by 15mg/kg/hr infusion. .

Lidocaine HydrochlorideDRUG

lidocaine hydrochloride 1.5mg/kg loading followed by 2mg/kg/hr infusion

Normal salineDRUG

Normal saline infusion with the same rate of infusion as the study drugs

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ASA physical status Ι or Π. * scheduled patients for brain tumor excision. Exclusion Criteria: * Hepatic, renal, cardiac, pulmonary, or endocrine impairment. * Signs of increased intracranial pressure or allergy to any of the used drugs.

Locations (1)

Ahmed ELbadawy

Cairo, Egypt

RECRUITING

Outcomes

Primary Outcomes

postcraniotomy emergence hypertension response to the study drugs

The number of the patients who have systolic blood pressure below 140 mmH during emergence of anesthesia after craniotomy for brain tumors in each group

Time frame: 4hours

Secondary Outcomes

Recovery time

Time till discharge from PACU

Time frame: 2 hours

Incidence of side effects of the used drugs

measure of safety

Time frame: 4 hours

Central Contacts

Ahmed ELbadawy, MD

CONTACT

01064249076 elbadawyahmed89@yahoo.com

Data from ClinicalTrials.gov

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