Impact of CO2 on Cerebral Blood Flow in Infants Less Than 6 Months During General Anaesthesia

St. Justine's Hospital60 enrolled

Overview

The study aims at assessing cerebral blood flow variations following expired CO2 variations in anaesthetized infants less than 6 months, during a routine general anesthesia.

The study aims at assessing cerebral blood flow (measured with Near-Infrared Reflectance Spectroscopy - NIRS - and transcranial Doppler - DTC) variations following end-tidal expired CO2 variations in anaesthetized infants less than 6 months, during a routine general anesthesia performed according to standards of care.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Anesthesia, General Infant

Interventions

EtCO2 modificationPROCEDURE

Controlled modification of EtCO2 through modification of ventilation parameters under general anesthesia without spontaneous breathing

Eligibility

Sex: ALLMax age: 6 MonthsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age \< or = 6 months * ASA class \< or = 3 * General anesthesia required for surgery Exclusion Criteria: * No parental consent * Emergency surgery * Preexisting neurological condition * Hemodynamic instability * Preexisting hypoxemia and/or hypercapnia * Laparoscopy or thoracoscopy, if expected EtCO2 level achieving would require unsafe ventilation parameters

Locations (1)

Sainte Justine's Hospital

Montreal, Quebec, Canada

Outcomes

Primary Outcomes

NIRS variation

Near-Infrared Spectroscopy value variation after EtCO2 modification

Time frame: 5 to 10 minutes

Secondary Outcomes

DTC variation

Transcranial Doppler values variation after EtCO2 modification

Time frame: 5 to 10 minutes

Data from ClinicalTrials.gov

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