The Efficacy and Safety of Sphenopalatine Ganglion Pulsed Radiofrequency Treatment for Cluster Headache

Inclusion Criteria: * diagnosis of cluster headache is confirmed according to the diagnostic criteria of the 2018 International Classification of Headache Disorders 3rd edition (ICHD-3); * patient's age is between 18 and 60 years; * patients seek treatment in the pain clinics of hospitals participating in the study within 5 days of the onset of the cluster period; pain conditions of patients remain the same after conservative treatment of conventional oral medication, or the reduction rates are less than 50% in pain degree during headache attacks, headache attack frequency, duration of each headache attack, and auxiliary analgesic drug dosage; and * patients signed the informed consent. Exclusion Criteria: * abnormalities in blood measurements, liver and kidney function, blood glucose, coagulation, electrocardiogram, and chest radiograph; * infection at the puncture site; * previous mental illness; * previous history of narcotic drug abuse; * history of anticoagulant and antiplatelet aggregation drugs; * implantable pulse generator; * previous history of invasive treatments such as sphenopalatine ganglion radiofrequency thermocoagulation and chemical destruction; * pregnant or breastfeeding patients.