Radiation-associated carotid vasculopathy is a common late sequelae in patients with head and neck cancer, which correlates with the incidence of stroke. Currently, little is known about the incidence of radiation-associated carotid vasculopahty in the context of intensity-modulated radiation therapy (IMRT). The aim of this study is to determine whether IMRT will increase the incidence of carotid vasculopathy in patients with nasopharyngeal carcinoma (NPC).
Study Type
OBSERVATIONAL
Enrollment
248
IMT measurements were performed using ultrasound machine in the pre-radiation and the post-radiation group. IMT was assessed at the common carotid artery (CCA) and the internal carotid artery (ICA) of both the left and right side.
Detection and measurement of plaques within internal carotid artery and common carotid artery by ultrasound
Velocity measurement of carotid artery to determine carotid stenosis
Fudan University Shanghai Cancer Center
Shanghai, Shanghai Municipality, China
intima media thickness of carotid artery
the intima media thickness of common carotid artery, internal carotid artery of the left or right side
Time frame: This is a cross-sectional study. So the time frame is within one week of a patient-visit to the clinics.
the incidence of carotid stenosis
Carotid stenosis is defined as the axial diameter of the carotid lumina decreases more than 50%.
Time frame: This is a cross-sectional study. So the time frame is within one week of a patient-visit to the clinics.
the number of carotid plaques
Carotid plaque is defined as a focal structure that encroaches into the arterial lumen of at least 0.5 mm or 50% of the surrounding IMT value or demonstrates a thickness \>1.5 mm as measured from the media-adventitia interface to the intima- lumen interface.
Time frame: This is a cross-sectional study. So the time frame is within one week of a patient-visit to the clinics.
total number of Montreal Cognitive Score (range: 0-30)
the higher the number, the better the cognitive function
Time frame: This is a cross-sectional study. So the time frame is within one week of a patient-visit to the clinics.
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Cognitive assessment
Cardiovascular risk factors include smoking, alcohol consumption, hypertension, diabetes mellitus, hypercholesterolemia, obesity. Cardiovascular diseases include ischemic stroke, ischemic coronary heart disease, TIA, etc.