The aim of this study is to compare the peripheral perfusion index values produced by equi-MAC of sevoflurane and desflurane in patients undergoing single-agent inhalation anesthesia.
Ether derivative anesthetics, including sevoflurane and desflurane, have direct activity on vascular tissue and both are vasodilators. However, there has been no direct comparison of vasodilative effect between sevoflurane and desflurane in vivo in humans. Peripheral perfusion index derived from photoplethysmographic waveform reflects peripheral vasomotor tone. Therefore, the purpose of this study is to compare the peripheral perfusion index values produced by sevoflurane and desflurane at equipotent concentration in patients undergoing single-agent inhalation anesthesia.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
70
End-tidal concentration of sevoflurane is maintained at age-corrected 1.0 minimum alveolar concentration throughout the study period.
End-tidal concentration of desflurane is maintained at age-corrected 1.0 minimum alveolar concentration throughout the study period.
Kangbuk Samsung Hospital
Seoul, South Korea
peripheral perfusion index
peripheral perfusion index value at a steady-state anesthesia of age-corrected 1.0 MAC
Time frame: After a 30-min waiting period from the induction of anesthesia
mean arterial pressure
mean arterial pressure at a steady-state anesthesia of age-corrected 1.0 MAC
Time frame: After a 30-min waiting period from the induction of anesthesia
heart rate
heart rate at a steady-state anesthesia of age-corrected 1.0 MAC
Time frame: After a 30-min waiting period from the induction of anesthesia
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