This study was designed to quantify the incidence of hyponatremia in patients of supratentorial/supra-sellar lesions and observe their effect on neurological morbidity and mortality.
Disorders of sodium and water balance are one of the commonly encountered problems while managing patients with neurological diseases. Managing such problems are challenging because the pathophysiology behind these disorders are complex and poorly understood and treatment of the injured brain itself can contribute to, and complicate the diagnosis of sodium disorders. Serum sodium disturbance can manifest as hypernatremia or hyponatremia. Hypernatremia usually occurs in the diabetes insipidus syndrome, whereas hyponatremia develops as a syndrome of inappropriate secretion of antidiuretic hormone (SIADH) or cerebral salt-wasting syndrome (CSWS). Because of the cerebral effects of hyponatremia, neurosurgical patients are at increased risk of complications including severe cerebral edema, mental status changes, seizures, vasospasm, and death. Though the problem of hyponatremia has been addressed in patients with different brain pathologies, this has not been studied in patients with non-sellar/suprasellar supratentorial tumors. This study was envisioned to quantify the incidence and magnitude of hyponatremia in this patient population and their subsequent neurological morbidity and mortality.
Study Type
OBSERVATIONAL
Enrollment
173
Measurement of serum sodium.
Mortality
To observe relationship between hyponatremia in supratentorial tumor patients and in-hospital mortality.
Time frame: From date of admission to hospital to date of Discharge from hospital or Death in hospital, whichever comes first, assessed up to 2 years from date of admission.
Duration of hospital stay
To observe relationship between hyponatremia in supratentorial tumor patients and duration of hospital stay.
Time frame: From date of admission to hospital to date of Discharge from hospital or Death in hospital, whichever comes first, assessed up to 2 years from date of admission.
Rate of admission in intensive care unit.
To observe relationship between hyponatremia in supratentorial tumor patients and rate of admission in intensive care unit.
Time frame: From date of admission to hospital to date of Discharge from hospital or Death in hospital, whichever comes first, assessed up to 2 years from date of admission.
Neurological deficits
To observe relationship between hyponatremia in supratentorial tumor patients and incidence of neurological deficits.
Time frame: From date of admission to hospital to date of Discharge from hospital or Death in hospital, whichever comes first, assessed up to 2 years from date of admission.
Seizures
To observe relationship between hyponatremia in supratentorial tumor patients and incidence of seizures.
Time frame: From date of admission to hospital to date of Discharge from hospital or Death in hospital, whichever comes first, assessed up to 2 years from date of admission.
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.