This study was a prospective, randomized, controlled, and double-blind trial. Major assessments were made during the operation and 48 h postoperatively.
The prime outcomes were the time in minutes from leave the postoperative care unit to the first patient-controlled intravenous analgesia press.The secondary outcomes were to compare the following: (1)blood concentrations of ropivacaine was measured at 0.5 h, 1 h, 2 h, 3 h, and 24 h after paravertebral nerve block; and (2) the patient's intraoperative opioid use, phenylephrine use, fluid intake, urine output, dry mouth score, and 24 h and 48 h visual analogue scale.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
154
combination of ropivacaine and dexmedetomidine 100 ug every time
combination of ropivacaine and dexamethasone 10mg every time
block with only ropivacaine
Department of Anesthesiology, the First Hospital of China Medical University
Shenyang, Liaoning, China
Change of thoracic paravertebral block analgesia duration
The prime outcomes were the time in minutes from leave the postoperative care unit to the first patient-controlled intravenous analgesia press
Time frame: Change from Baseline to 2 days after surgery
blood concentrations of ropivacaine
(The secondary outcomes were to compare the following: (1)blood concentrations of ropivacaine was measured at 0.5 h, 1 h, 2 h, 3 h, and 24 h after paravertebral nerve block; and (2) the patient's intraoperative opioid use, phenylephrine use, fluid intake, urine output, dry mouth score, and 24 h and 48 h visual analogue scale.
Time frame: Change from Baseline to 2 days after surgery
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