Tisagenlecleucel in Adult Patients With Aggressive B-cell Non-Hodgkin Lymphoma

Inclusion Criteria: * Histologically confirmed, aggressive B-cell NHL at relapse/progression or PR after front line therapy. Aggressive B-cell NHL is heretofore defined by the following list of subtypes (Swerdlow et al 2016): * DLBCL, NOS, * FL grade 3B, * Primary mediastinal large B cell lymphoma (PMBCL), * T cell rich/histiocyte rich large B cell lymphoma (T/HRBCL), * DLBCL associated with chronic inflammation, * Intravascular large B-cell lymphoma, * ALK+ large B-cell lymphoma, * B-cell lymphoma, unclassifiable, (with features intermediate between DLBCL and classical Hodgkin's Lymphoma (HL)), * High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements, * High-grade B-cell lymphoma, NOS * HHV8+ DLBCL, NOS * DLBCL transforming from follicular lymphoma * DLBCL transforming from marginal zone lymphoma * DLBCL, leg type * Relapse or progression within 365 days from last dose of anti CD20 antibody and anthracycline containing first line immunochemotherapy or refractory (have not achieved a CR). * Patient is considered eligible for autologous HSCT as per local investigator assessment. Note: Intention to transplant and type of high dose chemotherapy (HDCT) regimen will be documented at the time of study entry * Disease that is both active on PET scan (defined as 5-Deauville scorepoint-scale of 4 or 5) and measurable on CT scan, defined as:: * Nodal lesions \>15 mm in the long axis, regardless of the length of the short axis, and/or * Extranodal lesions (outside lymph node or nodal mass, but including liver and spleen) \>10 mm in long AND short axis * Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1 * Adequate organ function: Renal function defined as: * Serum creatinine of ≤1.5 x upper limit of normal (ULN), OR estimated glomerular filtration rate (eGFR) ≥ 60 mL/min/1.73 m2 Hepatic function defined as: * Alanine Transaminase (ALT) and Aspartate Transiminase (AST) ≤ 5 × ULN * Total bilirubin ≤ 1.5 x ULN with the exception of patients with Gilbert syndrome who may be included if their total bilirubin is ≤3.0 × ULN and direct bilirubin ≤1.5 × ULN Hematologic Function (regardless of transfusions) defined as: * Absolute neutrophil count (ANC) \>1000/mm3 * Absolute lymphocyte count (ALC) \>300/mm3 OR Absolute number of CD3+ T cells \>150/mm3 (only for patients with non-historical apheresis) * Platelets ≥50000/mm3 * Hemoglobin \>8.0 g/dl Adequate pulmonary function defined as: * No or mild dyspnea (≤ Grade 1) * Oxygen saturation measured by pulse oximetry \> 90% on room air * Forced expiratory volume in 1 s (FEV1) ≥ 50% and/or carbon monoxide diffusion test (DLCO) ≥50% of predicted level - Must have a leukapheresis material of non-mobilized cells available for manufacturing. Exclusion Criteria: * Prior treatment with anti-CD19 therapy, T cell therapy, or any prior gene therapy product * Treatment with any systemic lymphoma-directed second line anticancer therapy prior to randomization. Only steroids and local irradiation are permitted for disease control * Patients with active central nervous system (CNS) involvement by disease under study are excluded, except if the CNS involvement has been effectively treated and local treatment was \>4 weeks before randomization * Prior allogeneic HSCT * Clinically significant active infection * Any of the following cardiovascular conditions: * Unstable angina, myocardial infarction, coronary artery bypass graft (CABG), or stroke within 6 months prior to screening, * Left ventricle ejection fraction (LVEF) \<45% as determined by echocardiogram (ECHO) or magnetic resonance angiography (MRA) or multigated acquisition (MUGA) at the screening assessment. * New York Heart Association (NYHA) functional class III or IV (Chavey et al 2001), within the past 12 months. * Clinically significant cardiac arrhythmias (e.g., ventricular tachycardia), complete left bundle branch block, high-grade atrioventricular (AV) block (e.g., bifascicular block, Mobitz type II) and third degree AV block unless adequately controlled by pacemaker implantation. * Resting QTcF ≥450 msec (male) or ≥460 msec (female) at screening or inability to determine the QTcF interval * Risk factors for Torsades de Pointes (TdP), including uncorrected hypokalemia or hypomagnesemia, history of cardiac failure, or history of clinically significant/ symptomatic bradycardia, or any of the following: * Long QT syndrome, family history of idiopathic sudden death or congenital long QT syndrome * Concomitant medication(s) with a "Known Risk of Torsades de Pointes" per crediblemeds.org that cannot be discontinued or replaced by safe alternative medication. * Patients with active neurological autoimmune or inflammatory disorders (e.g., Guillain-Barré Syndrome (GBS), Amyotrophic Lateral Sclerosis (ALS)) and clinically significant active cerebrovascular disorders (e.g. cerebral edema, posterior reversible encephalopathy syndrome (PRES))