Multiple-dose Tolerability and Pharmacokinetic Studies of Benapenem inClinical Healthy Subjects

Inclusion Criteria: * Male or female healthy subjects, aged 18\~45; * Body weight ≥ 50 kg and body mass index 19.0\~24.0 kg/m2; * To the test, physical examination, blood routine, urine routine, liver and kidney functions, and related examinations normal, or mild abnormalities in indicators while without clinical significance as indicated by the investigator; * Normal or mild abnormalities without clinical significance in the standard 12-lead ECG; * Signing informed consent form. Exclusion Criteria: * Regular smoking, alcohol abuse, and drug abuse; * Use of drugs with known damage to an organ within three months; * History of specific allergies , or history of drug allergy, especially those allergic to lactams and excipients of test drug; * Febrile illnesses within three days before the screening; * Patients with mental illness or psychotic disorder in the past; * Past nervous system diseases (epilepsy, stroke, cerebrovascular disorder, etc.), gastrointestinal disorder (such as stomach ulcers, gastritis, etc.) or disorder of other systems (such as cardiovascular, respiratory, hematological, or endocrine system, etc.) diseases or medical history. * Habitually taking any medication, including traditional Chinese medicine; * Having taken any medication that may affect test results within two weeks before the screening, such as antibiotics, NSAIDs, aluminum- or magnesium-containing antacids, diuretics, anticoagulants, central nervous system depressants, and any drug that may affect the drug absorption; * Having participated in other investigational drug trial in the preceding three months; * Blood donation for 360 ml or more within three months before the screening; * Heart rate\<50bpm or \>100bpm; 12)Systolic blood pressure \<90 mmHg or ≥140 mmHg, diastolic blood pressure ≥90mmHg or \<60mmHg; * Women who are pregnant or breastfeeding, or who may be pregnant without adopting acceptable contraception, or who have a positive result in serum pregnancy test; * Women who are planning to become pregnant within 6 months, or male subjects who are planning to make his spouse pregnant within 6 months; * HBsAg, HCV antibody, HIV antibody, and Treponema pallidum antibody positive; * Urine drug-of-abuse testing positive; * Any other factor that makes the subject not suitable for the trial as indicated by the investigator.