Combination Therapy With 3BNC117 and 10-1074 in HIV-Infected Individuals

* INCLUSION CRITERIA: General Inclusion Criteria for both Groups: 1. Age 18-65 years old. 2. HIV-1 infection and clinically stable. 3. General good health and has an identified primary health care provider for medical management of HIV infection and is willing to maintain a relationship with a primary health care provider for medical management of HIV infection while participating in the study. 4. Cluster of differentiation 4 (CD4)+ T cell count \>450 cells/mm(3) at screening. 5. Laboratory values within pre-defined limits at screening: 1. Absolute neutrophil count \>1,000/mm(3). 2. Hemoglobin levels \>10.0 g/dL for men and \>9.0 g/dL for women. 3. Platelet count \>100,000/mm(3). 4. Estimated or a measured glomerular filtration rate \>60 mL/min/1.73m(2) as determined by the National Institutes of Health (NIH) Clinical Center laboratory. 5. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels of \<2.5 times upper limit of normal (ULN), direct bilirubin within the normal range for the NIH Clinical Center laboratory. 6. Willingness to have samples stored for future research. Inclusion criteria specific for Group 1: 7. Institution of ART within 12 weeks of being diagnosed with primary HIV-1 infection 8. Primary HIV-1 infection is defined as meeting at least one of the following criteria: 1. Detectable plasma HIV-1 RNA levels of \>2000 copies/mL with a negative result from an HIV-1 enzyme immunoassays (EIA), or 2. Positive result from an HIV-1 EIA with a negative or indeterminate result from an HIV-1 western blot or another confirmatory antibody test that subsequently evolves to a confirmed positive result, or 3. Negative result from an HIV-1 EIA within the past 4 months and HIV-1 RNA levels of \>400,000 copies/mL, in the setting of a potential exposure to HIV-1. 4. Negative result from an HIV-1 EIA within 6 months prior to a positive result from an HIV-1 EIA and an HIV-1 western blot or another confirmatory antibody test. 5. Presence of low level of HIV antibodies as determined by having a positive EIA or a positive Western blot with a non-reactive detuned EIA according to a serologic testing algorithm for recent infection. 9. Documentation of continuous ART treatment with suppression of plasma viral level below the limit of detection for greater than or equal to 1 years. Individuals with blips (i.e., detectable viral levels on ART) prior to screening may be included provided they satisfy the following criteria: 1. The blips are \<400 copies/mL, and 2. Succeeding viral levels return to levels below the limit of detection on subsequent testing. 10. Willingness to undergo ATI 11. Willingness for both male and female subjects to agree to use barrier protection methods or abstinence during the ATI phase of the study to decrease the risk of HIV transmission. Inclusion criteria specific for Group 2: 12. No ART within 24 months of screening. 13. HIV plasma viremia between 200 and 5,000 copies/mL at screening AND at least two documented viral level greater than or equal to 200 copies/mL in the 12 months prior to screening. At the screening visit, subjects considering enrollment in Group 2 will be advised that current guidelines recommend treatment of all individuals with HIV infection regardless of viral levels and CD4 counts. Reproductive Risks Contraception: The effects of 3BNC117 and 10-1074 on the developing human fetus are unknown. For this reason, men and women of childbearing potential must agree to use adequate pregnancy prevention. This includes the use an effective method of contraception (i.e. condom with spermicide, diaphragm with spermicide, hormone-eluting intrauterine device (IUD), hormone-based contraceptive with condom) for the study duration. Subjects should also agree to use a male or female condom while off ART. Pregnancy prevention must be practiced continuously for the duration of study participation. Females of childbearing-age must have a negative pregnancy test result prior to receiving each infusion of 3BNC117/10-1074. During the course of the study, if a female subject, or the partner of a male subject suspects or in fact becomes pregnant, the effected subject should inform the study staff immediately, as well as the woman s primary care physician. EXCLUSION CRITERIA: 1. Chronic hepatitis B, as evidenced by a positive test for hepatitis B surface antigen (HBsAg), or chronic hepatitis C virus (HCV) infection, as evidenced by a positive test for HCV RNA. Subjects with a positive test for HCV antibody and a negative test for HCV RNA are eligible. 2. HIV immunotherapy or vaccine(s) received within 1 year prior to screening. 3. Any licensed or experimental non-HIV vaccination (e.g., hepatitis B, influenza, pneumococcal polysaccharide) received within 2 weeks prior to study enrollment. 4. Receipt of other investigational study agent within 28 days of enrollment. 5. Any active malignancy that may require systemic chemotherapy or radiation therapy. 6. Systemic immunosuppressive medications received within 3 months prior to enrollment (Not excluded: \[1\] corticosteroid nasal spray or inhaler; \[2\] topical corticosteroids for mild, uncomplicated dermatitis; or \[3\] oral/parenteral corticosteroids administered for non-chronic conditions not expected to recur \[length of therapy less than or equal to10 days, with completion in greater than or equal to 30 days prior to enrollment\]). 7. History or other clinical evidence of: 1. Significant or unstable cardiac or cerebrovascular disease (e.g., angina, congestive heart failure, recent stroke or myocardial infarction). 2. Severe illness, malignancy, immunodeficiency other than HIV, or any other condition that, in the opinion of the investigator, would make the subject unsuitable for the study. 8. Active drug or alcohol use or any other pattern of behavior that, in the opinion of the investigator, would interfere with adherence to study requirements. 9. Pregnancy or breast-feeding at time of screening. 10. Documented multiclass antiretroviral drug resistance that, in the judgment of the investigator, would pose a risk of virologic failure should additional mutations develop during the study (Group 1 only). Co-enrollment Guidelines: Co-enrollment in other trials is restricted to observational studies or those evaluating the use of a licensed medication and is subject to approval of the principal investigator (PI).