Patients with traumatic rib fractures not receiving regional anesthesia through a epidural or nerve block catheter will be recruited for the study. Once enrolled, they will be randomized to receive either intravenous lidocaine or intravenous saline for control of pain related to their rib fractures. In addition, they will receive other pain medications, such as acetaminophen, gabapentin, and opioid pain medications. Our primary outcome is a decrease in their opioid medication requirements.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Intravenous bolus of lidocaine (1.25 mg/kg) and then infusion at 1 mg/kg/hr
Intravenous bolus of saline and then infusion
Stanford Hospital and Clinics
Palo Alto, California, United States
Opioid pain medicine usage
Total opioid pain medicine usage
Time frame: Average per 24 hours
PCA requirements
Percentage of patients requiring PCA
Time frame: 5 days
Pain score
Average pain scores
Time frame: 5 days
Length of stay
Average length of stay in ICU and hospital
Time frame: 5 days
Respiratory failure
Rates of pneumonia or other respiratory failure (pneumonia defined as (1) new pulmonary infiltrate on chest X-ray and (2) two of three of the following: (a) productive cough (b) WBC \> 12,000 and (c) temperature \> 38.0)
Time frame: 5 days
Death
Mortality rate between two groups
Time frame: up to 30 days
Mobility
Highest level of mobility on hospital day #2
Time frame: 2 days
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