Recent evidence suggests a decline in fertility of persons living with HIV (PLWH) (delayed pregnancies, sponteanous abortions, especially when patients receive an antiretroviral therapy, early menopause, amenorrhea and anovulatory cycles) with a possible decrease in ovarian reserve. However, indications of fertility preservation by freezing oocytes are nevertheless not clearly identified. The objective of this study is to evaluate the ovarian reserve before and after the implementation of antiretroviral treatment in PLWH for whom the diagnosis of HIV has just been made.
This is a monocentric prospective cohort study with minimal risk and constraints. Ovarian reserve is compared between two groups: 30 PLWH, at time of diagnosis and 6, 12 and 18 months after initiation of an antiretroviral therapy, and 30 HIV negative women attending medically assisted procreation consultation for male infertility, age, BMI and smoking habits matched.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
60
Blood test and pelvic ultrasound are performed at each visit to evaluate ovarian reserve
Blood test and pelvic ultrasound are performed at each visit to evaluate ovarian reserve
Chu Clermont-Ferrand
Clermont-Ferrand, France
change from inclusion visit AMH level at 18 months
blood test to evaluate ovarian reserve thanks to AMH
Time frame: M0 (inclusion visit) and M18 (after 18 months)
antral follicle count
pelvic ultrasound to evaluate ovarian reserve thanks to antral follicle count
Time frame: Month 0 (inclusion visit), Month 6 (after 6 months), Month12 (after one year), Month18 (after 18 months)
estradiol, lutenizing hormone and follicle-stimulating hormone test
blood test
Time frame: Month 0 (inclusion visit), Month 6 (after 6 months), Month 12 (after one year), Month18 (after 18 months)
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