Genotype 164 adults to evaluate six selected single nucleotide polymorphisms (SNPs) (rs1006737, rs10994336, rs10994133, rs2238071, rs1051375, rs1024582) for use as a genetic biomarker to differentiate between bipolar depression and unipolar depression.
Adults ages 18-80 will be recruited if they are diagnosed with bipolar disorder, major depression, or have no mood symptoms. The adults will undergo a diagnostic interview, the Mini International Neuropsychiatric Interview (MINI) for the diagnosis. The subjects will also complete the Adverse Childhood Events Scale to evaluate for a genetic x environmental interaction in detecting bipolar disorder at initial assessment. Genotyping will be done by SNaPshot genotyping method and genetic sample will be collected via buccal swab.
Study Type
OBSERVATIONAL
Enrollment
164
genotyping using SNaPshot genotyping method.
Helen and Arthur E Johnson Depression Center
Aurora, Colorado, United States
Logistic Regression
Logistic regression will be used to examine a genetic risk score using a risk allele count as the independent variable, with a diagnosis of BD versus MDD versus those with no mood diagnosis as the dependent variable.
Time frame: 1 year
Genetic Risk Score
Genetic risk score of selected SNPsrs1006737, rs10994336, rs10994133, rs2238071, rs1051375, rs1024582
Time frame: 1 year
Family History
Positive family history of bipolar disorder in a first degree relative
Time frame: 1 year
Adverse Childhood Experiences Scale
0-10 item scale assessing for adversity experienced during childhood
Time frame: 1 year
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