Postural abnormalities represent disabling and painful complications in patients with Parkinson's disease (PD). The stooped posture is a typical feature of PD but with advancing of disease more severe body abnormalities can affect people with PD. These deformities include Pisa syndrome, camptocormia, antecollis, scoliosis and striatal deformities related to hand (striatal hand) and/or toes (striatal toes).
Postural abnormalities represent disabling and painful complications in patients with Parkinson's disease (PD). The first postural trunk deviation in PD was first described by James Parkinson himself and recognized as stooped simian appearance, with flexion of the hips and knees, and rounding of the shoulders. Although the stooped posture is a typical feature, more severe spinal misalignment (and deformities) can affect people with PD. These postural deformities include Pisa syndrome (PS), camptocormia (CP), antecollis (AC), scoliosis (S) and striatal deformities related to hand (striatal hand) and/or toes (striatal toes). The prevalence of these postural deformities is variable because several diagnostic criteria have been used to characterize each deformity. Recently, a consensus of diagnostic criteria has been reached in literature permitting us to better mapping the presence of these deformities in people with PD.
Study Type
OBSERVATIONAL
Enrollment
794
Department of Experimental and Clinical Medicine - University "Politecnica delle Marche" Ancona -Italy. Neurorehabilitation Clinic - Azienda Ospedaliero Universitaria Ospedali Riuniti di Ancona.
Ancona, Italy
RECRUITINGDepartment of Neuroscience, Imaging and Clinical Sciences, University G.d'Annunzio of Chieti-Pescara
Pescara, Italy
The prevalence of postural deformities
% of people with Parkinson's disease reporting Pisa syndrome, camptocormia, antecollis, scoliosis and striatal deformities related to hand (striatal hand) and toes (striatal toes).
Time frame: 1 day
Data of birth
(day/month/year);
Time frame: 1 day
Sex
(male/female)
Time frame: 1 day
Body Mass Index
(score)
Time frame: 1 day
SPECIFIC EVALUATION FOR PATIENTS WITH PARKINSON'S DISEASE • Age at PD onset
(years)
Time frame: 1 day
Disease duration of PD
(years)
Time frame: 1 day
Modified Hoehn and Yahr (H&Y);
Total score of Modified Hoehn and Yahr staging scale. It evaluates the stage of Parkinson's disease. Range= 1 to 5. Higher values represent worse stages of disease.
Time frame: 1 day
Unified Parkinson's Disease Rating Scale (UPDRS);
The Unified Parkinson's Disease Rating Scale evaluates the motor and non-motor symptoms of Parkinson's disease. Range= 0 to 260. Higher values represent worse symptoms of disease.
Time frame: 1 day
PD phenotype
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Neurology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
Pisa, Italy
RECRUITINGIRCCS San Raffaele CTC Centro Parkinson Via della Pisana 235, 00163 Roma
Roma, Italy
RECRUITINGDipartimento di Neuroscienze A.O. Città della Salute e della Scienza di Torino
Torino, Italy
RECRUITINGClinica Neurologica, Dipartimento di Scienze Neurologiche, Chirurgiche e della Salute, Azienda Ospedaliera Universitaria integrata, Universita' di Trieste
Trieste, Italy
RECRUITINGDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona
Verona, Italy
RECRUITING(rigid acinetic; tremor; mixed type)
Time frame: 1 day
Laterality of motor symptoms at PD onset
(right, left, bilateral);
Time frame: 1 day
Clinical asymmetry
(number of patients)
Time frame: 1 day
Quality of life by means of Parkinson's Disease Questionnaire-8;
Parkinson's Disease Questionnaire-8 evaluates quality of life in patients with Parkinson's disease. Range= 0 to 100. Higher values represent worse quality of life.
Time frame: 1 day
Latency between PD onset and start of antiparkinsonian therapy
(years)
Time frame: 1 day
Pharmacologic treatment at disease onset of PD
(levodopa; dopaminoagonists; L-Dopa + dopaminoagonist; other therapies)
Time frame: 1 day
Ongoing pharmacological therapy
(levodopa; dopaminoagonists; L-Dopa + dopaminoagonist; other therapies)
Time frame: 1 day
Levodopa equivalent daily dose
(mg)
Time frame: 1 day
Number of falls and direction
(number, anterior, posterior, right, left)
Time frame: 1 day
Comorbilities
(heart diseases, malignancies, diabetes, hypertension, mental disorders, obesity, metabolic disorders, cerebrovascular diseases, physical trauma)
Time frame: 1 day
Associated medical conditions
(osteoporosis, arthrosis, rheumatic diseases, otovestibular disorders)
Time frame: 1 day
Visual Analogue Scale (VAS)
Visual Analogue Scale evaluates pain intensity. Range= 0 to 10. Higher values represent higher pain intensity.
Time frame: 1 day
SPECIFIC EVALUATION FOR PATIENTS WITH ABNORMAL POSTURES Type of deformity
(Pisa syndrome, camptocormia, anterocollis, scoliosis, striatal deformities)
Time frame: 1 day
Degrees
(wall goniometer and pictures with software-based analysis)
Time frame: 1 day
Latency to develop one or more postural deformity after PD onset
(months)
Time frame: 1 day
Postural deformity duration
(years)
Time frame: 1 day
The pattern of postural deformity onset
(acute, subacute, chronic)
Time frame: 1 day
Postural deformity after drug modification
(yes/no)
Time frame: 1 day
Postural deformity awareness
(yes/no)
Time frame: 1 day
Head compensation
(in case of PS, CP, AC)
Time frame: 1 day
Neck head on trunk angle
(degrees)
Time frame: 1 day
Neck tilt angle
(degrees)
Time frame: 1 day
Head tilt angle
(degrees)
Time frame: 1 day
Gaze angle (in case of AC)
(degrees)
Time frame: 1 day
Ankle and hip flexion (in case of CP)
(degrees)
Time frame: 1 day
Sensory trick
(yes/no)
Time frame: 1 day
Postural deformity direction only for PS
(right/left)
Time frame: 1 day
The presence of metronome sign (in case of PS)
(yes, no)
Time frame: 1 day
Side of PD symptoms at onset and PS inclination
(ipsilateral, contralateral, bilateral)
Time frame: 1 day
Side of PD symptoms at onset and hands/feet deformities
(ipsilateral, contralateral, bilateral)
Time frame: 1 day