OCT vs IVUS vs QCA to Guide Moderate-to-severe Calcified Lesion Stent Implantation

Inclusion Criteria: * Subject must be 18 to 80 years age * Subject (or legal guardian) understands the trial requirements and the treatment procedures and provides written informed consent before any trial-specific tests or procedures are performed; * Subject is eligible for percutaneous coronary intervention (PCI); * Subject has symptomatic coronary artery disease with objective evidence of ischemia or silent ischemia (including NST-ACS, stable CAD and STEMI（duration over 4 weeks）); * Subjects are eligible candidates for coronary artery bypass graft surgery (CABG); * Left ventricular ejection fraction (LVEF) detected by cardiac ultrasound within 30 days ≥ 30%; * Subject is willing to comply with all protocol-required follow-up evaluation. Angiographic Inclusion Criteria (visual estimate): * The target lesion must be a new lesion and has moderate-to-severe calcification which located in a visually estimated reference diameter ≥2.5 mm and ≤4.0 mm in native coronary artery; * Target lesion diameter stenosis ≥70% and ≤99% * Target lesion length ≤70mm * Judgment of moderate-to-severe calcification: * Grade II (moderate) calcification: Before angiography with or without contrast agent injected, the opacity and deformation of coronary artery can be basically seen, the contour of coronary artery can be basically seen and the contrast agent can fully cover the opacity of blood vessel * Grade III (severe) calcification: Before angiography with or without contrast agent injected, the opacity and deformation of coronary artery can be basically seen, the contour of coronary artery is clearly visible and the contrast agent can partially cover the opacity of blood vessel * Grade IV (extremely severe) calcification: Before angiography with or without contrast agent injected, the opacity of coronary artery can be clearly seen, the contour and deformation are completely visible, and whether the contrast agent is injected is not highly correlated with the changes in the opacity density of blood vessel. Exclusion Criteria: * Subjects recently suffer from STEMI (within 4 week), and ECG changes/clinical symptoms consistent with AMI or accompanied with increased cardiac biomarkers (CK-MB, CK, TNT or TNI) , and if any of the following criteria is meet in the procedure, patients are excluded; CK-MB\> 2ULN, regardless of the value of total CK; total CK\> 2ULN, CK-MB or Tn is abnormal; If CK-MB or CK was not detected, but cTN\> 1ULN, and at least one of the following: schemic symptoms and ECG changes of new ischemia; Development of pathologic Q waves in the ECG; Imaging evidence of new loss of viable myocardium or new regional wall motion abnormality. * Subject with hemodynamic instability or severely decreased activity tolerance (KILLIP classification \>2 or NYHA classification \>2 ); * Severely ejection fraction reduced heart failure ( LVEF \< 30%) * Subjects were detected ventricular aneurysm greater than 3.0\*2.0cm or intraventricular thrombosis by cardiac ultrasonography in 30 days; * Subjects had an organ transplant or are waiting for an organ transplant; * Subjects are receiving chemotherapy or will receive a chemotherapy within 30 days after PCI; * Subjects are undergoing chronic (over 72 hours) anticoagulant therapy (such as heparin and coumarin) other than acute coronary syndrome; * Subjects have confirmed or suspected liver disease, including hepatitis lab results; * Subjects with elevated serum creatinine level \>3.0mg/dL or undergoing dialysis therapy * Subjects with active peptic ulcer, active gastrointestinal (GI) bleeding or other bleeding diathesis or coagulopathy, or refused a blood transfusion; * Subjects with cerebral vascular accident (CVA) or transient ischemic attack (TIA) in the past 6 months, or with permanent nerve defects; * Subjects had any PCI (such as balloon angioplasty, stent, cutting balloon,atherectomy) treatment in target vessels (including collateral) within 13 months prior to baseline; * Within10mm proximal or distal to the target lesion (including branch artery) had received any PCI prior to baseline; * Non target vessel had got any PCI in 24 hours prior to baseline; * Subjects plan to undergo PCI or CABG in 13 months after the baseline PCI; * Subjects have any coronary endovascular brachytherapy treatment previously; * Subjects associated with drugs allergy (such as sirolimus, or structure-related compounds fluorinated polymers, thiophenepyridine or aspirin); * Subjects are suffering from other serious illness (such as cancer, congestive heart failure), which may cause drop in life expectancy to less than 13 months; * Subjects are currently abusing drugs (such as alcohol, cocaine, heroin, etc); * Subject plan to undergo any operations that may lead to confuse with the programme; * Subjects were participating in another study of drug or medical device which did not meet its primary endpoint; * Subjects plan to pregnant within 13 months after baseline; * Subjects are pregnant or breastfeeding women. Angiographic Exclusion Criteria (visual estimate): * Target lesions with the following criteria: More than 2 target vessel and 2 target lesion Left main Ostial lesion Bifucation lesion( stenosis \>70%), branch vessel diameter ≥2.5 mm and lesion length more than 5mm Target lesion located in saphenous vein grafts or arterial grafts Via saphenous vein grafts or arterial graft to treat the target lesion Thrombosis in target lesion Endomembrane tear in target lesion Restenosis in stent prior to the procedure Chronic total occlusion * Subjects with unprotected left main coronary artery disease (diameter stenosis \>50%); * Subjects have a protected left main coronary artery disease (diameter stenosis\> 50% and left coronary artery bypass surgery), as well as target lesions located in the LAD and LCX; * Subjects with other lesions of clinical significance, may be need intervention within 13 months after baseline. * Either reason (ig. severe tortuosity, etc) causing stent improperly placed and positioned