The Use of Bispectral Index Monitoring to Assess Depth of Sedation in Patients With Traumatic Brain Injury

University of Aberdeen26 enrolled

Overview

An observational study to assess the BIS reported level of sedation of patients with traumatic brain injury in the ICU.

Patients admitted to Aberdeen ICU with severe traumatic brain injury will have a BIS electrode placed and observed for 24 hours. The study team will be blinded to the result, so not to influence treatment. All clinical care is at the discretion of the clinical team.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Traumatic Brain Injury

Interventions

BIS MonitorDEVICE

Unilateral BIS electrode

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adults (over 18) * Diagnosis of traumatic brain injury * Expected to survive * Expected to require greater than 24 hours of sedation and mechanical ventilation Exclusion Criteria: * Brain injury thought to be unsurvivable by ICU clinical team * Frontal decompressive craniectomy * Use of ketamine infusion at recruitment or planned use within 24 hours * Fractured frontal bone or severe overlying soft tissue injury * Simple extradural haemorrhage with no other obvious intracranial injury * Pregnant patient

Locations (4)

Intensive Care Unit, Aberdeen Royal Infirmary

Aberdeen, United Kingdom

NHS Tayside

Dundee, United Kingdom

NHS Lothian

Edinburgh, United Kingdom

Leeds Teaching Hospitals NHS Trust

Leeds, United Kingdom

Outcomes

Primary Outcomes

Mean BIS for Population Over 24 Hours

Mean BIS of patients sedated. BIS is a processed EEG value ranging from 0 to 100, with lower values representing decreased brain activity. The usual range for General Anaesthesia is 40-60.

Time frame: 24 hours

Secondary Outcomes

Mean ICP for Population Over 24 Hours

Mean ICP of sedated patients

Time frame: 24 hours

Incidence of Osmotherapy Use for Population Over 24 Hours

Number of instances of osmotherapy use in sedated patients

Time frame: 24 hours

Median Vasopressor Dose for Population Over 24 Hours

Total vasopressor dose for sedated patients

Time frame: 24 hours

Sedative Dose for Population Over 24 Hours

Total sedative dose for sedated patients

Time frame: 24 hours

Length of ICU Stay for Population Over 24 Hours

Number of days admitted to ICU

Time frame: Days to weeks

Data from ClinicalTrials.gov

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