In this study 45 patients undergoing weekly dialysis for chronic end stage renal disease will be enrolled. The patients will be treated with a standard dialysis solution, containing acetate buffer, for 3 months; subsequently the acetate will be substituted with citrate anion for the 3 following months and then, the last 3 months, the standard acetate-solution will be restarted. The aim of the study is to assess if acetate-to-citrate switch in the dialysis solution influences dialysis efficiency and patient inflammatory state.
Study Type
INTERVENTIONAL
Purpose
TREATMENT
Masking
NONE
Enrollment
45
Solution A: 3mmol/L of acetate anion; Solution B: 1mmol/L of citrate anion
Città della Salute e Della Scienza di Torino - Presidi CTO e Molinette
Torino, To, Italy
Change in serum CRP (C-reactive protein)
Change in serum CRP during the 3 months of citrate-buffered dialysis
Time frame: Months 4th to 6th
Change in dialysis efficiency
Dougirdas formula will be used to estimate dialysis efficiency at the beginning and completion of each study interval
Time frame: Every 3 months (month 0, 6, 3 and completion - 9)
Change in serum CRP (C-reactive protein)
Variation of serum CRP at the beginning and completion of each study interval
Time frame: Every 3 months (month 0, 6, 3 and completion - 9)
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