Recombinant Human Endostatin in Combination With XELOX Therapy in Patient With Advanced Colorectal Cancer.

Inclusion Criteria: * Clear pathology diagnosis of stage for the Ⅳ period of advanced colorectal cancer. * There are at least 1 imaging examinations according to the standard of RECIST（the longest diameter is at least 10mm with spiral CT and 20mm with ordinary CT）. * Male or female , age 18～75 * Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1. * The patients had to have a life expectancy of at least 3 months. * A white blood count (WBC) greater than 3000/mm3, platelets greater than 100 000/mm3, and normal coagulation values. * Aspartate aminotransferase (AST) and adenosine triphosphate (ALT) values were to be less than 2.5 times the upper limit of normal;a bilirubin level of less than 25 lmol/l；a creatinine value less than 130 lmol/l. * Informed consent was obtained from all patients. Exclusion Criteria: * Patients having a brain tumor or brain metastases, a bleeding disorder, receiving anti-coagulant therapy. * a history of myocardial infarction or angina pectoris in the last 6 months or uncontrolled congestive heart failure, having an active infection or receiving radio- or chemotherapy within 4 weeks before study. * patients with uncontrolled serious medical or psychiatric illness or having any other condition that was likely to interfere with regular follow-up.