Bloodstream Infection Due to Multidrug-Resistant Organisms - Multicenter Study on Determinants of Clinical Outcomes

University Hospital Tuebingen6,000 enrolled

Overview

Continual surveillance of both community-acquired and nosocomial bloodstream infections for specific target organisms. Analysis of comorbidities, complications, bacterial resistance patterns, bacterial genomics (e. g. via WGS and MLST typing) for the determinants of clinical outcomes. The clinical outcomes are investigated both in the short-term (up until discharge) and the long-term (six months after index blood culture by standardized questionnaire). A predictive point-of-care score is to be developed based on these data to define high-risk patient populations requiring more intensive diagnostic and/or treatment regimens.

Study Type

OBSERVATIONAL

Enrollment

6,000

Conditions

Bloodstream Infection Septic Shock

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * At least 18 years old * Informed consent given either by patient or guardian * Inpatient * At least one blood culture positive for one of the following bacteria: Staphylococcus aureus, Enterococcus spp., Escherichia coli, Enterobacter spp., Klebsiella spp., Acinetobacter baumannii, Pseudomonas aeruginosa Exclusion Criteria: * Less than 18 years old * Not capable of giving informed consent nor informed consent given by guardian * Outpatient * No blood cultures positive for any of the target organisms

Locations (6)

Universitätsklinikum Tübingen

Tübingen, Bade-Württemberg, Germany

RECRUITING

Universitätsklinikum Freiburg

Freiburg im Breisgau, Baden-Wurttemberg, Germany

RECRUITING

Justus-Liebig-Universität Gießen

Giessen, Hesse, Germany

RECRUITING

Universitätskliniken Köln

Cologne, North Rhine-Westphalia, Germany

RECRUITING

Universitätsklinikum Schleswig-Holstein

Lübeck, Schleswig-Holstein, Germany

RECRUITING

Charité - Universitätsmedizin Berlin

Berlin, Germany

RECRUITING

Outcomes

Primary Outcomes

Short-term mortality due to bloodstream infection

Mortality due to bloodstream infection up to hospital discharge in association to causative species, resistance pattern, comorbidities, complications etc.

Time frame: From index blood culture to discharge, an average of 16 days

Long-term mortality due to bloodstream infection

Mortality due to bloodstream infection up to long-term follow-up after 6 months in association to causative species, resistance pattern, comorbidities, complications etc.

Time frame: Up to 6 months

Long-term morbidity due to bloodstream infection

Morbidity as measured by the SF-36 questionnaire due to bloodstream infection after 6 months in association to causative species, resistance pattern, comorbidities, complications etc.

Time frame: At 6 months

Bloodstream Infection Due to Multidrug-Resistant Organisms - Multicenter Study on Determinants of Clinical Outcomes

Overview

Conditions

Eligibility

Locations (6)

Outcomes

Primary Outcomes

Central Contacts