The study evaluates the protective effect of low-dose aspirin use on gastrointestinal cancers (colorectal, esophageal and gastric cancers) in long-term users, episodic users and non-users of aspirin in Taiwan.
The primary objective is to investigate the protective effect of long-term low dose use of aspirin on colorectal, esophageal and gastric cancer in adult subjects from Taiwan. Secondary objectives are to evaluate the protective effect by duration of low-dose aspirin use on colorectal cancer, the effect of discontinuation of aspirin on colorectal cancer prevention, the staging distribution of colorectal cancer and the description of fatal cases due to colorectal cancer. Aspirin use will be identified through Taiwanese National Health Insurance (NIH) data from 2000 to 2015. Cancer cases and staging of the three cancer types will be ascertained through the Taiwan Cancer Registry, using data from 2000 to 2014. Fatal cases will be ascertained using Mortality database from 2000 to 2015.
Study Type
OBSERVATIONAL
Enrollment
4,710,504
Low dose of aspirin, i.e. \< 150 mg daily
Non-consumers
National University of Taiwan Hospital
Taipei, Taiwan
Number of subjects with colorectal cancer
Number of subjects with colorectal cancer for each cohort (long-term, episodic and former users of aspirin, and non-users).
Time frame: Up to 14 years
Number of subjects with esophageal cancer
Number of subjects with esophageal cancer for each cohort (long-term, episodic and former users of aspirin, and non-users).
Time frame: Up to 14 years
Number of subjects with gastric cancer
Number of subjects with gastric cancer for each cohort (long-term, episodic and former users of aspirin, and non-users).
Time frame: Up to 14 years
Duration of aspirin use to colorectal cancer
The duration of low-dose aspirin use in years to colorectal cancer.
Time frame: Up to 14 years
Time from aspirin discontinuation to colorectal cancer
Period of time in years from discontinuation of aspirin use to detection of colorectal cancer.
Time frame: Up to 14 years
Stage of colorectal cancer
The stage of cancer will be determined according to the International Classification of Diseases for Oncology (ICD-O-3).
Time frame: Up to 14 years
Number of fatal cases due to colorectal cancer
Derived from Taiwan Mortality database.
Time frame: Up to 14 years
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