Booster Dose of HCG for Unruptured Follicle in Non IVF/ICSI Cycles

Tanta University110 enrolled

Overview

This study will be conducted to assess the effect of booster dose of hCG on the unruptured follicles in non IVF/ICSI cycles.

In this study enrolled patients (n=160) who underwent controlled ovarian stimulation and timed intercourse with unruptured mature graffian follicle 48 hours after IM 10,000 IU HCG dose. Patients were allocated randomly into intervention group and control group. In the intervention group another booster dose (10,000 IU of hCG) was given IM while in the control group 2 ml normal saline was given IM leaving follicles for spontaneous rupture

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

110

Conditions

LUF - Luteinised Unruptured Follicle Syndrome

Interventions

hCGDRUG

A booster dose (10,000 IU of hCG) was given IM 48 hours after first triggering dose

Saline SolutionDRUG

2 ml of normal saline will be injected 48 hours after first triggering dose

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Ordinary stimulated cycles * IUI stimulated cycles * Unruptured follicle after 10000 IU IM HCG triggering Exclusion Criteria: * IVF/ICSI cycles

Locations (1)

Ayman Shehata Dawood

Tanta, Algharbia, Egypt

Outcomes

Primary Outcomes

Ovulation rate

rupture of dominant follicle manifested by disappearance of follicle and presence of free fluid in douglas pouch

Time frame: 48 hours

Secondary Outcomes

Pregnancy rate

Number of cases with positive serum pregnancy test

Time frame: 15 days

Data from ClinicalTrials.gov

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